http://bit.ly/HYSlFe
Aggressive prostate cancer linked to two deletions in human genome
from the press release (linked above):
"An international research team led by Weill Cornell Medical College
investigators have discovered two inherited-genetic deletions in the human
genome linked to development of aggressive prostate cancer. The findings,
published online today in the Proceedings of the National Academy of Sciences
(PNAS), indicate a man's risk of developing prostate cancer either triples or
quadruples, depending on the genetic variant they inherit...
According to the lead co-authors, the study is potentially groundbreaking
because it demonstrates that so-called copy number variations (CNVs) in either
protein coding or non-coding areas of the human genome play a significant role
in the development of cancer in general, and in aggressive prostate cancer,
specifically...
The two genetic variants identified by the research team are not the only cause
of aggressive prostate cancer, Dr. Demichelis says. 'These variants likely
collaborate with other factors early in a man's life leading to development of
prostate cancer.' "