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Rising PSA, multiple biopsies and no PCa

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Posted 8/4/2012 1:07 PM (GMT 0)
Have had rising PSA since 2007. First concern was 2009 when it went over 4. Had numerous biopsies to include a color doppler guided saturation biopsy all were negative. Not even any suspicious cells or signs of inflamation. Yet my PSA continues to rise, over 6 now.

Prostatis, BPH and infection all ruled out. Scheduled for another saturation biopsy later this month. Anyone have a similar story who might be able to offer some advice?

Posted 8/4/2012 11:20 PM (GMT 0)
Gregz263

Sorry - I have no idea at all.

What are you getting from your medical team?

Hugs!

Bud

We will beat this crap!
Posted 8/5/2012 1:07 AM (GMT 0)

I think they are all scratching their heads a bit.

I think I have done everything I can do.

Annual Color doppler scan, 6 month PSA tests....

Numbers indicate likely PCa, but nothing found. Doc says he sees some "abnormailities" on my doppler ultrasound but he saw the same on my first scan in 2010 and "throughly" sampled those areas in a guided saturation biopsy, finding nothing. Says those areas look unchanged. He was even comfortable waiting another 6 months before another biopsy.....I am not willing to wait.

I realized it was a long shot but was hoping someone out there had the answer

Posted 8/5/2012 3:08 AM (GMT 0)
Greg,
Welcome. I was in a similar stituation for 10 years, but my psa was rising much faster. Your doubling time is well over 4 years which is a good sign indicating that if you do have cancer it is most likely low grade or indolant. It is also growing less than .75 per year which is also a good sign.
have you had a PCA 3 test and a free psa?
The annual CDUs should identify any major growth before it gets out of hand. Right now you are doing all you can. There are instances of "psa leak" in which a high psa is normal in some individuals and usually stabalizes at some point.
I know what you are going through is very frustrating. but you are taking all the correct steps.
Posted 8/5/2012 9:06 AM (GMT 0)
I have/had a good friend who's PCS hoovered around 12 for several years. 4 or 5 biopsies where clean. Last biopsy came back positive for PC and off he went to radiation.

Liver cancer got him a few years after the radiation treatments.
Posted 8/5/2012 11:53 AM (GMT 0)
Thanks for the replies.
PSA was stable in mid 4 range for about 18 months, now climbing again.
FPSA was done, around 7-8%.
PAP was also done last time, not sure what those numbers mean yet but it was .75
Posted 8/31/2012 10:10 AM (GMT 0)
Completed my second saturation biopsy yesterday. Dr. took 52 samples. I have to say things are a bit sore today. Dr. stated that if he does not get a hit on this bio there is no cancer in the prostate and time to consider looking elsewhere.

Now we wait.......
Posted 8/31/2012 11:42 AM (GMT 0)
OK Greg, let us know how it goes.
Posted 8/31/2012 1:02 PM (GMT 0)
Greg, thanks for the update, was wondering if you had any new info. Waiting and hoping for good results...
Posted 8/31/2012 1:15 PM (GMT 0)
My older brother has had a similar experience. His PSA went as high as 9, but three biopsies have found no cancer. He did learn that he had a very enlarged prostate. Now he's on Avodart or one of the other similar drugs and is being watched carefully, but his PSA's now are down in the 2 range and he's apparently fine. Good luck to you.
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