I believe I read in the book Beyond Hormone therapy by Mark Moyad, that although the concepts are related, that Radium/Alpharadin 223 does work better and something to do about
it being 'alpha' rather than 'beta', if my memory is working well. It was in his book and he made it seem like this is an improvement over the older Samarium and Strontium. Don't know anyone whom has used this, yet.
From website info: Alpha particles differ from beta particles in energy (MeV), tissue range, linear-energy transfer (LET), and number of DNA hits needed to kill a cell.[30] Radionuclides of interest in alpha-radionuclide therapy[31,32] include 225Ac, 213Bi, 211At, and 223Ra, or Alpharadin. Radium-223 is one of the most promising candidates for high- LET alpha-particle irradiation of cancer cells on bone surfaces. Unlike beta-emitting radiopharmaceuticals, alpha-pharmaceuticals deliver an intense and highly localized radiation dose (with a range of 2 to 10 cell diameters) to bone surfaces.[30] Radium-223 and its daughter radionuclides are thus much more potent, causing double-stranded DNA breaks leading to cell death,[33] but with substantially less irradiation of healthy bone marrow than standard bone-seeking beta-emitters. Thus, 223Ra does not require cells to cycle in order to achieve its antitumor effect. This distinct advantage is of particular benefit in the treatment of prostate cancer, which has a low proliferative rate
Post Edited (zufus) : 11/25/2012 11:40:02 AM (GMT-7)