Recommended video from PCRI (Prostate Cancer Research Institute) 2006 video with Harry Pinchot's laymens questions to the panel of PCa experts: (oncologists)- Dr. Tucker (now over in Asia still), Dr. Shevrin (Chicago), Dr. Myers, Dr. Sartor, Dr. Vogelzang and (urologist) Dr. Chodak. Great questions still very relevant to us right now, this video is about
HT therapies, 2nd line therapy drugs and chemotherapies. They do these PCRI events every year and all are worth seeing. In this video discussions on the LHRH, anti-androgens, keto, leukine, estrogenics., thalidomide, pc-specs, prostasol, vegf factor drugs and chemo's are all somewhat discussed.
Example from this one Dr. Tucker had a patient with Gleason 6 and only one core positive, but he had a psa of 26 and while using proscar. Didn't make sense to have a psa that high, so he decided to order an MRI and the findings were: 5 mets spots on spine, thoracic and lumbar areas. Now this is atypical of a Gleason 6 and one core positive patient, however high psa and while on proscar (maybe double his psa to 50 then) and you see the found results.
They had discussions on how a person could have stabil psa numbers and yet PCa growth could still be possible or happening. Dr. Sartor mentioned that with scans you need 1cm approx. of cells grouped together to show up on a scan, which would equal around 1-billion PCa cells. So, you could have various spots in your body with say millions of cells and not show up on any scans. (perhaps a CTC test might be worth considering for growth comparisons)?
Seems the old PC-specs was pretty effective in patients and had maybe 8 herbal ingredients, including some traces of DES (which is not a real contaminate to begin with), prostasol is not as effective and Dr. Myers and some others didn't really think it is all that great. I knew of guys using pc-specs back in the days and they were happy to get it and use it and swore by it.....later I think the loss of sales via the establishment helped to get it labelled as a contaminant type status and get it banned. (whatever)
This is not in the video but PCa variants are out there and still being discovered, that should tell you that they cannot easily define whom has a variant type, so the stats out there of say there being only 1.5-3.0% of PCa's as being variants should come with the caveat 'as far as they can tell' not every pathologist knows what the heck he is seeing, they are still having fun with Gleason grading. Not mention DNA ploidy testings that could be done on PCa to see how far from normal diploid paired DNA stranding are you found with.
There are examples of appearances of cures which defy norms of PCa like in the case of Dr. Fred Lee, now 33 yrs. alive with incureable PCa. Dr. Myers with fabulous results in his originally incureable PCa and surely some others. Also, like my example mentioned above Gleason 6 with found multiple mets to spine. Nothing about this is simplistic or easily defined in every patient, each case is unique and unto its own. The one size fits all approaches in HT therapies is imperfect (useable stuff, but not custom tailored). Sequencing or using combos and even revisiting some drugs have proven results in many cases.
NOTEWORTHY- friend of mine whom has been in the PCa world since like 1995 with high psa, failed surgery and then failed SRT, had a Gleason 9, has done various hormone manipulations and alot of it on his own doings using 5 different docs in order to obtain various drug Rx's over the years. I have his PCD history with psa's and drug useages. The shorter story and more recent results are rather astounding: he failed lupron via psa's around 16 months ago approx., he did estradiol patches and gels with results, his psa got up to 2.3 not long ago. He is going to get me the list of drugs and items he did just recently and it includes revisiting Lupron, after a few weeks on this new therapy drugs (none are extreme- no thalidomide or leukine or chemo or heavy duty things), he most recent psa is .007 
which is kind of unheard of in a patient using HT therapies over 10 years+ and failed on Lupron prior. Once I get the data on which drugs or in sequence thereof I would post it and he said I could. If this method holds water for anyothers....I would say it is 'new' territory for PCa consideration. To go from 2.3 in this scenario of time and history of drugs and achieve .007 is very unheard of as far as I have witnessed anywhere. These are the kinds of things I am interested in hearing or knowing about, even if it doesn't benefit me personally. This guy is a pioneer and my salute to anyone whom travels that type of path, with all of its unknowns.