John
BIND-014 is in Phase I. With Phase II and III ,a preparation of an application and FDA processing it might be 3+ years out..
CRLX-101 is awaiting Phase II results for lung cancer. (No prostate trials noted.) It is also a nanoparticle med similar to BIND-014. Could be out in 2 years or so for lung cancer.
These two are nanoparticles with a poison attached that preferentially attack cancer cells.
There are also Antibody Drug Conjugates with an antibody attached to molecules that attack cancer. ADC.
This is my pipeline report:
PROSTATE CANCER PIPELINE REPORT Dec.22, 2012
RADIUM-223 Chloride (Alpharadin) Radiopharmaceutical for bone mets NDA pending
cabozantinib / Cometriq / XL184 approved for thyroid cancer / Phase III prostate cancer
custirsen sodium (OGX-011) Phase III blocks clusterin, cell survival protein (fast track)
Prostvac / Prostvacf vaccine in trials Phase III aka PSA-tricom vaccine (fast track)
Tasquinimod (TASQ) Phase III prostate cancer anti-angiogenesis med
orteronel / TAK-700 androgen synthesis inhibitor in trials Phase III CYP-17 target
ProstAtak vaccine by injection into prostate Phase III with radiation
ARN509 Phase II androgen receptor agonist
ODM-201 androgen receptor agonist early Phase II
PSMA ADC Phase II antibody drug conjugate with cell poison
OGX-427 heat shock 27 inhibitor Phase II prostate cancer with prednisone
Capesaris (GTx-758), oral nonsteroidal estrogen receptor agonist early Phase II
AEZS-108 Phase II targeted therapy with cell poison
NX-1207 injection into prostate tissue Phase II cancer, Phase III for BPH
G-202 prodrug turns to poison after contacting PSMA Phase II
TOK-001 galeterone Phase I complete CYP-17 target androgen receptor
DSTP3086S anti-STEAP1 ADC Phase I prostate cancer (Zimac trial)
177Lu-J591 radio-immunotherapy in trials PSMA target
APC-100 APC-300
INK128 in trials mtor inhibitor Phase I prostate cancer
Ad5-CMV-NIS gene therapy plus radioactive iodine Phase I Mayo Clinic
Kevetrin / Thioureidobutyronitrile P53 target in Phase I solid tumors
CRLX-101 nanoparticle with cell poison Phase II lung cancer Ukraine
BIND-014 nanoparticle with cell poison Phase I in USA
JX-594 virus that infects/kills cancer cells Phase II some cancers.
ganetespib heat-shock 90 treatment in Phase III some cancers
There are many lesser known meds in trials for prostate cancer.
There are scores of trials for new meds for solid tumors and unspecified cancers.