IP-6 Revisited...

I remember stumbling across this when I was first diagnosed, a lone researcher had discovered that a dietary supplement IP-6 seemed to suppress the spread of PC..Now other researchers have discovered the same thing...

www.ucdenver.edu/academics/colleges/pharmacy/aboutUs/aboutSchoolPharmacy/Pages/Research.aspx

Here's the Abstract from Pubmed.

Inositol Hexaphosphate Inhibits Tumor Growth, Vascularity, and Metabolism in TRAMP Mice: A Multiparametric Magnetic Resonance Study.

Raina K, Ravichandran K, Rajamanickam S, Huber KM, Serkova NJ, Agarwal R.

University of Colorado Denver, 12850 E. Montview Blvd, C238, Room V20-2118, Aurora, CO 80045.

Herein, employing anatomical and dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI), we evaluated noninvasively, the in vivo, chemopreventive efficacy of inositol hexaphosphate (IP6), a major constituent of high-fiber diets, against prostate tumor growth and progression in transgenic adenocarcinoma of the mouse prostate (TRAMP) model. Male TRAMP mice, beginning at 4 weeks of age, were fed with 1%, 2%, or 4% (w/v) IP6 in drinking water or only drinking water till 28 weeks of age and monitored using MRI over the course of study. Longitudinal assessment of prostate volumes by conventional MRI and tumor vascularity by gadolinium-based DCE-MRI showed a profound reduction in tumor size, partly due to antiangiogenic effects by IP6 treatment. As potential mechanisms of IP6 efficacy, decrease in the expression of glucose transporter GLUT-4 protein together with an increase in levels of phospho-AMP-activated kinase (AMPK(Th172)) were observed in prostate tissues of mice from IP6 fed-groups, suggesting that IP6 is interfering with the metabolic events occurring in TRAMP prostate. Investigative metabolomics study using quantitative high-resolution (1)H-NMR on prostate tissue extracts showed that IP6 significantly decreased glucose metabolism and membrane phospholipid synthesis, in addition to causing an increase in myoinositol levels in the prostate. Together, these findings show that oral IP6 supplement blocks growth and angiogenesis of prostate cancer in the TRAMP model in conjunction with metabolic events involved in tumor sustenance. This results in energy deprivation within the tumor, suggesting a practical and translational potential of IP6 treatment in suppressing growth and progression of prostate cancer in humans. Cancer Prev Res; 6(1); 40-50; ©2012 AACR.

Some of the same researchers a few years ago:
Inositol Hexaphosphate Suppresses Growth and Induces Apoptosis in Prostate Carcinoma Cells in Culture and Nude Mouse Xenograft: PI3K-Akt Pathway as Potential Target

www.ncbi.nlm.nih.gov/pubmed/19920184

The full text of this one is available online: cancerres.aacrjournals.org/content/69/24/9465.long

It makes for interesting (if difficult) reading.

Finally, the page on Inositol Hexaphosphate from cancer.org: www.cancer.org/treatment/treatmentsandsideeffects/complementaryandalternativemedicine/dietandnutrition/inositol-hexaphosphate

If SRT is to work at all, the sooner you start it the better, but 7.5 years out, SRT is a LONG shot.....The Pomegranate, cuminum and IP-6 probably work just as well and they don't cost $10,000 a month...

Treating cancer is the economic backbone of the medical industry..If they ever found a real cure, it would be a disaster for them...