6 mo. doubling time unchanged after itraconazole study...what next?

My husband is 61, had open surgery in '09, salvage radiation in '10, on IHT3 for 1 year, off until rising psa (.08)in Oct. 2012. We were then referred by our local oncologist to Dr. Charles Ryan at UCSF. He felt we could monitor psa bi-monthly until it reached 1 point something and then go from there. That happened in March '14. He suggested we get in a UCSF study using itraconazole, a drug used to treat toenail fungus that has also been shown to slow prostate cancer in about 30% of study participants. Had negative bone scan and MRI before starting the study in May, 2014. Started the itraconazole in June (psa 1.44) had about 4 months in the middle of the study where the psa went down or stayed the same(stayed right around 2.5 from Sept. to Dec. 2014) but then started going up in Jan. and is now 3.36. this is a doubling time of 6.2 months, and we are now out of the itraconazole study. Dr Ryan has suggested we can either go back on hormone therapy or enter a 3-arm clinical trial testing ARN 509 alone, with Lupron, or Lupron alone. The trial is not blind, so you know what you're getting. Dr Ryan is actually comfortable with his psa rising further, seeing as how if we got the ARN 509 alone arm of the trial, there is no guarantee that there would be any psa suppression. Part of me just wants him to get back on hormone therapy and get to undetectable again. We like Dr. Ryan--he assures us he wouldn't suggest a treatment that would put my husband at further risk, that we are not "guinea pigs." His gleason after surgery was 4 +3 with seminal vesicle invasion on one side, 2 pos. margins. Does anyone have any info./opinions on this trial? Think it's too risky with rising psa? Any other Dr. Ryan patients? Healing Well has been an incredible source of support and information, and I thank you all in advance.

I have been a patient of Chucks for over 5 years. When I initially became refractory, he put me in the ARN 509 study....I did remarkably well with my PSA dropping to less than 0.05.Unfortunately I developed a secondary cancer from my SRT and got bounced from the trial. It worked well for me.....I trust Chuck completely.