More information on Pomegranate

Yooper, the link is no longer working. Says the information is no longer stored. I did a search on that sight and I think I found the article. So anyone interested, try this link...

www.sciencedirect.com/science/article/pii/S0955286307002719


I wanted to start taking pomegranate juice, figuring it may or may not help, but it can't hurt. But I noted the high sugar content, which would mess me up on Triglycerides, which for me are more or less under control, but have been as high as 750 in the past.

Thanks for posting this

Post Edited (Pratoman) : 4/12/2015 9:07:45 AM (GMT-6)

Hedging my bets while worrying about the sugar and associated calories I take 3oz of pomegranate juice a day with my most protein rich, lowest fat meal which is lunch. Using a FITBIT I watch it all daily,calories in/out, carbs, fats, sodium, etc. Not gaining weight on HT is hard work....

Let's keep hoping there's something to it...can't hurt right?
Dave has been taking Life Extensions Pomegranate 2x daily since diagnosis. Was drinking his 8oz daily too, but just got sick of the taste---and its also $15 a bottle here for 3 eight oz glasses. Crazy!

I don't take it. Guess I am going to die...

It may be just me, but I can't seem to get pass the opening screen and can't access the study nor the graphs on the left.

Thanks,
Jerry

ok...thanks.

Did the article give any numbers...like, that it increased PSADT, number of guys involved in the study, and other conclusions?

thanks

Thanks John, it was me that mentioned the sugar issue (which is stupid since I ate a half pint of cookie dough ice cream last night).
I thought about that (the pills). Honestly though, there are so many studies and so many that contradict each other, that I am at a point where I feel like I should just eat whatever I want whenever I want, and maybe not even take supplements anymore. Its all so confusing and the truth is, nobody knows for sure whats good and whats bad..

I've taken a POMx capsule a day for the past five years. the capsule is equivalent to an 8 oz glass of juice, is sugar and calorie free and is vegan. costs me less than a buck a day to have the capsules delivered via subsrcription.

POMx is proven to slow the progression of prostate cancer and does many other good things for your body. period.

prostate cancer is an "old man's" disease and many old guys are distrustful and pig-headed so I understand the hesitance to discuss pomergranate even though it's proven to work.

ed

Just ordered a boatload of the pills from Amazon.

As far as supplements go I am of the same mind as Yoop: if there is a peer reviewed study backing the stuff I am "down" but otherwise don't take them.

Mag, yes that link is another "spin" as you've suggested - problem is that was from 2012 when all of the advertising junk was going back and forth. The study I referenced is from a year later, and again is very, very sound.

I took it for the last few years. But now that my PSA is going up faster, it answers my question. I always asked if there was indication that it at least slowed the PSA increase, and could not prove either way. Now I think I can say it may have retarded the increase, but it certainly did not stop it.

A Yooper said...
Prato, doesn't sound like you bro - bad day? For me, I only look to supp's, foods, vitamins, etc. that have passed sound, medical/science based studies. When it comes to pomegranate I found plenty, including an abstract I found that was presented at ASCO 2nd June 2013 and the Journal of Clinical Oncology 31, 2013. Further, this trial was approved by the National Ethics Committee, peer reviewed by National Cancer Research Institute (NCRI) Complementary Therapies Research Committee and adopted by the National Cancer Research Network.

"Conclusions: In this study, it was shown that men taking the whole food supplement had a significantly lower median percentage rise in PSA compared to men taking a placebo (P<0.0001). The difference in percentage rise in PSA between these groups from the start to end of the study was large (63.8%); and as the patient characteristics were well-balanced and the trial had sufficient numbers to ensure adequate statistical power, the results of this study offer clinically meaningful guidance for men contemplating nutritional supplements after prostate cancer."

"The randomization process was outsourced and independently audited by an external agency to ensure adherence to European Good Clinical Practice Guidelines. The data was externally audited before independent analysis at Cranfield University."

Sound enough for me.

Me too. I take the approach that unless there is significant evidence of harm, and there are several studies of this type that look good, I am likely to err on the side of taking the food or supplement. I am not going to hold my breath waiting for a study meeting FDA standards for a new drug to be applied to a non-patentable substance. Because, IMO, unless it can be patented no such studies are going to be done. Although, if the study sponsors are part of big pharmacy, and they are pretty sure they can supply evidence that the supplement is worthless or harmful, then you might see a big enough study resulting in negative results.

Is this the study you refer to? :
www.ncbi.nlm.nih.gov/pmc/articles/PMC4020278/
A chart from the study:
www.ncbi.nlm.nih.gov/pmc/articles/PMC4020278/figure/fig3/

Also:

Somebody said...
A separate analysis of the cohort of men managed with AS (n=121) revealed that in the FSG the mean PSA dropped by 0.14% (95% CI −7.57 to 7.95),
whereas in the PG it rose by 46.98% (95% CI 28.51–68.31)

And finally:

Somebody said...
The authors thank the charities Prostate Action and The Primrose Oncology Fund for sponsoring this study and the enthusiasm and co-operation of the participants. The full trial protocol is available on cancernet.co.uk/pomi-t.htm. Peer reviewed sponsorship was received from the charity ‘Prostate Action', and the study was also supported by ‘The Primrose Oncology Fund'. No sponsorship was received from the UK manufacturer of the investigational supplement used in this study.
Go to:
Notes

The authors declare no conflict of interest.

Hopefully there is no bias and none of these sponsers are the makers of Pomi-T. Hopefully.

I also found some studies on Pom that were not so positive. Just like when we have discussed some other non-prescription drug approaches, sometime the studies are very impressive on the positive side, sometimes less so and sometimes indicate the substance is worthless or rarely even harmful. Since all of these studies come from- usually- respected universities or medical centers, it is amazing how the results can be so different.

But bias of the investigators and who is sponsoring them must always be considered. Although, it is hard for me to figure out what the bias might be that would influence a university or medical center to find great results for any non-patentable substance. Much easier to understand if researchers are related somehow to the big pharmaceuticals why they might possibly have a bias against a non-patentable substance.