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Fathers who produce only daughters 40% more at risk for PCa?

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Posted 7/29/2015 1:06 PM (GMT 0)
That's what the article linked below claims: that fathers who have produced only daughters and no sons are at a 40 % higher risk for PCa.

The presumption according to the article is that the Y-chromosome is somehow defective in these men, which, in the words of the article, "… ties Y chromosome loci to prostate cancer."

The article also claims to have found "… a strong trend for a decrease in prostate cancer risk as the number of sons increased."

The article dates from 2007, but after a quick websearch I find no updating material, so I assume the points of the article are still valid, or at least have not been challenged.

But it's also clearly just one of those statistical things. Although I myself am the father of two sons, that didn't stop the beast from paying me a visit!

www.news-medical.net/news/2007/01/03/21278.aspx
Posted 7/29/2015 1:39 PM (GMT 0)
Great. At this point, I suppose it doesn't matter to me why I got it. Males for generations with prostate problems? Check. 3 daughters, no sons? Check. Too much red meat in my diet? Check. White, Northern European? Check. Does it matter? Nope.
Posted 7/29/2015 8:16 PM (GMT 0)
halbert, same here. I'm 65, diagnosed in 2010, treated in 2011. I have a cousin with prostate cancer, 3 biological daughters, no sons, eat red meat, etc. But does it matter? Maybe to my sons-in-law. So far, they each have one son. I'll encourage them to have more. But daughters are so delightful!
Posted 7/29/2015 10:39 PM (GMT 0)
Interesting. Three daughters, no sons here. Read meat consumption (who doesn't outside of Asia?).

Study says my hazard ratio is 1.6, pretty strong, high confidence level.

===========================================

2002 - 2015, age 63 now
12/02 PSA 2.9 age 51
9/03 BX/DX, Gleason 6, 4 of 12 cores
9/03 Brachytherapy
5/08 PSA nadir 1.1
12/08 PSA 1.8
2/09 BX/DX, Gleason 8, 1 of 12 cores
6/09 Hyperthermic Radiation, Hormone (short term), IMRT (10 fractions) spring 2009
10/09 PSA nadir < 0.1 10/09 through 01/12
4/12 PSA 0.2
3/14 PSA 2.9
5/14 C11 Acetate PT/CT, found 2.0 cm lymph node
5/14 Lupron/Casodex (9 months)
8/14 nadir <0.01
2/15 SBRT to node
3/15 PSA 0.02,T=0
6/15 PSA<0.015,T=105 (yippee!)
Posted 7/29/2015 11:52 PM (GMT 0)
with 3 siblings, I am the only one with sons and the only one with PC.

I have a greek word for this study-bologna or as we say it in the south" balonie"
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