What Johns Hopkins says (Walsh himself, no less!) is that men with positive surgical margins and GS≥7 (regardless of EPE) should receive adjuvant radiation.
Immediate Adjuvant Radiation Therapy Following Radical Prostatectomy Should Not Be Advised for Men with Extraprostatic Extension Who Have Negative Surgical MarginsHowever, Chris King says, not so fast Patrick!
Chris King said...
This insightful editorial highlights the surprisingly continuing challenge of managing post-prostatectomy patients well. While in complete agreement with the authors that following staid guidelines from the AUA and ASTRO would be a mistake, I propose going even further, and simpler—let’s not advise postop radiation until there is proven and measurable disease. Unlike for nearly all other cancers, we do have a tumor marker [uPSA] that is perfectly reliable (with extremely rare exceptions) down to one part in a billion in terms of sensitivity.
The three adjuvant radiation therapy (RT) trials mentioned in the article continue to be misunderstood and misused. These trials compared adjuvant RT with observation, not adjuvant RT vs salvage RT. The observation arm received too little too late, so no wonder it was an inferior arm. These trials proved nothing and have led to much overtreatment and confusion. There are three ongoing trials1-3 based on this very premise—adjuvant RT vs early salvage RT (summarized in the table below). Based on many retrospective studies suggesting that initiation of early salvage RT yields equal outcomes to adjuvant RT, this approach has become the rational and logical approach for many clinicians. It is expected that these trials will provide definitive answers in the near future, and I fully anticipate they will finally resolve this controversy.
http://www.practiceupdate.com/c/34448/2/3/
He also did an analysis that showed that among men with pT2, irrespective of margin status, a cutoff of 0.03 ng/ml on a first uPSA was predictive of later BCR, and any postop uPSA ≥ 0.03 ng/mL captured all failures missed by analyzing only the first postop value (100% sensitivity). He also found that in men with pT2, positive margin status was associated with longer time to biochemical recurrence (86 months) than negative margin status (33 months).
Ultrasensitive PSA Identifies Patients With Organ-Confined Prostate Cancer Requiring Postop RadiotherapyBased on King, you have nothing to lose by waiting until your uPSA reaches 0.03 ng/ml, if it does.
- Allen