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Posted 1/24/2017 6:21 PM (GMT 0)
Hi Guys

I'm 12 years in from my first confirmation of Prostate Cancer. PSA was 10.5 when discovered and had a 7.5 Gleason - it had already spread to the testicular walls. Did Radiation for 10 weeks and 4-1/2 years of hormone therapy, which seemed to keep it under control. Hormone therapy was eliminated and still kept a 2 to 3 PSA Range. 2 years ago it really shot up - 35 PSA and Chemo was administered. PSA retreated to 15, then shot back up to 30 in three to 4 months. Did the immune therapy treatment, then started on Xtandi which I am on now. Unfortunately PSA increasing again. MRI confirms small tumor in the Lymph Nodes, but no indication of spreading to other organs or bones. I see on line that the average time span once spread to the Lymph Nodes has occurred is around 32 months. Question is, are there any other treatments that I can bring to the attention of my Oncolosyst?? I'm only 63 and don't want to leave my loved ones so soon. Thanks for any input.

Best regards
Dennis
Posted 1/24/2017 7:18 PM (GMT 0)
Welcome, others with more knowledge should be along shortly...

With that said I think if they can find it they can zap it if you haven't had the max gy's for the area. There are also lots of trials you might quality for.

Lymph nodes and 32 months I think should only be a back of the napkin kind of thing. PC is so variable, many here have been stage 4 for many years and still going strong. Some will no doubt have some concrete advice for you.

So for now, welcome. Keep us informed and draw upon the wealth of knowledge accumulated here.

Jon
Posted 1/24/2017 7:31 PM (GMT 0)
Thanks for the input. I asked about radiation for the tumor in the lymph notes. Was told it would do More damage than good. Any input appreciated
Posted 1/24/2017 9:05 PM (GMT 0)
Hi Dennis-

It sounds like you are working with a good oncologist.

You said, "MRI confirms small tumor in the Lymph Nodes, but no indication of spreading to other organs or bones." MRI isn't very good at detecting infected LNs - it only shows enlarged LNs that may or may not be metastatic. But the bigger question is what to do about any you find. There are no data that show any survival improvement from zapping individual metastases, although it might drive PSA down for a while. Radiation of individual metastases is only standard of care for bone mets that might fracture or cause pain.

But it sounds like you might be a good candidate for a very promising clinical trial. They are looking for men who are castration-resistant but do not yet have any confirmed distant metastases. It uses a radioactive element, Lu-177, that is targeted to prostate cancer cells specifically. Here are the details:

/clinicaltrials.gov/ct2/show/NCT00859781

At the bottom is a list of places that are recruiting patients for this trial. Feel free to contact them directly - they are usually thrilled to talk to patients.

For more info on this kind of therapy, here are some articles about it:

/pcnrv.blogspot.com/2016/08/will-lu-177-anti-psma-be-next-xofigo.html
/pcnrv.blogspot.com/2016/08/lu-177-psma-update.html
/pcnrv.blogspot.com/2016/10/lu-177-psma-617-another-update.html
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