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New to board have been a silent folllower for 2 1/2 yrs. Briefly hex at that time gleanson 8 psa 40.
Surge no option felt it may have extended out of prostate. Bone scan and Ct neg. Had 25 radiation tx seed implants and been on lupin for 2 1/2 yr. lowest psa was o.47 9 mo ago 12/16 1.2 and now2.5. Repeat Ct and bone scan neg. They did do MRI of L hip for a suspicious area which turn out to be a insufficient fracture. The RO recommends med onc delta scan. He is ok waiting to start casodex for a while. Has anyone had a fracture related to lupron? w
What are your thoughts?

Hey Minn17 & Thomasjohn:

I have been on Lupron since late summer of 2015. Regarding effectiveness, something went hay-wired with my situation 1st week of March this year. PSA numbers shot up and then a bone scan detected mets to one spot in a bone in my chest area. So my lupron stopped performing and the cancer got really aggressive all of a sudden.

Only problem I have had with lupron is hot flashes. Sometimes I can be working in my yard and will have one right after the other. I just stop what I am doing and drink water like crazy. Never had any broken bones. Frequency of urination is nuts as well. Up every hour to hour & a half each night. When you dealing with gleason 8's like we are, I guess you have to put up with a lot of unwanted stuff.

I start Provenge theraphy this coming Monday so I hope it kicks in soon. Will see.

Greetz, and welcome out. Been there myself.

2 & 1/2 years of Leuprolide chemo. Am almost back to normal pituitary function now, 2 & 1/2 years after the last dose of Eligard.

While I was on Luprolide, I was out with my Labrador Retriever for our daily 7 miles, while running at about 5.5 mph, I tripped on an exposed concrete sidewalk edge across the trail at a street crossing. I caught myself nicely enough with both hands palms down flat with my forearms face to the side, but my left hand and wrist got a bunch of "strange spiral" fractures parallel to the joins and my left pinkie knuckle exploded into many small shards. The ER docs were entertained with the novelty, but squealed on me to my team. They hit me up with Prolia right away and gave me the lecture about not breaking myself any more.

The hand works well enough, we just left the bone fragments in place. I had to quit a lot of my daily training regimen for a couple of years due to that injury. BTW, the side effects of the Prolia can be entertaining as well.

Hey Thomasjohn,

To answer your question on the Provenge, they said my veins weren't strong enough so they pout in a port.

I guess I could say I have been fortunate not to break any bones. I still consider myself being pretty active.
I will agree with trailguy on the Prolia. That is some crazy stuff. My teeth were fine before, but now I am spending a lot of money at the dentist office. I don't know if I will take another shot or not. I know it is suppose to help protect your bones but at a cost I can't continue to pay out, if you know what I mean.

Tn Lee,
I had a few injections of xgeva samething as prolia. For bone strengthening right? Well one of my CT showed something in my head (I know there is not much there, lol) which the oncologist questioned. It turned out my leftside of my head had and still has a major sinus infection. They thought it could be cancer thank God it was not. So I went to ENT several meds then 2 1/2 hour surgery 10/2015 still did not fix the infection, two ENTs threw up their hands. Went to my dentist he pulled three good upper molars which became loose in one sitting and some of my facial bone that had broken away above the teeth. Now that was a heck of alot of fun last april. Still I have a major sinus infection. I sniff like Iam sniffing lines of cocaine, I believe caused by xgeva. And some ask me why will I not take infusion chemo (been asked by docs three times) I got enough "crap" in my body. Maybe some guys do fine with xgeva and chemo but I will never take that again. Trailguy said "entertaining" I understood what he meant, no thanks. One day soon I might just toss the zytiga out the window and go smoke pot in Denver and pop my oxy until. Also I had so much radiation in me I got pulled out of security line at midway airport 11/2015 from all my CT's and bone scans. I blew up the homeland security sensors. I tried to tell them I am not a terrorist but thank God I had all my notes with me to prove I just came from CTCA in Zion. I got a lot of crazy looks from people. So I guess Iam just a natural organic guy, who take the bare min. regarding these powerful drugs. Now my doc is talking xofigo I will bunt on that one for sure. Maybe Iam just one of those guys that the major side effects are written about. Hey guys its all good.

Sorry these fingers and hands are just to arthritic to do this well. I am waiting for the VA to decide if they will ok a med onc as I am only seeing a urologist. Also waiting to see what to do about stress fracture. They did think the fracture was a result of both and radiation and lupron. I am concerned also with the rising psa. I was told by the urologist that we have a very Aggressive ca. Good luck to all.

Hi RobLee,

The problem I have had with Prolia has been all dental. After receiving the shot I began to have pain and discomfort in my gums. It wasn't a constant discomfort and would move around. Sometimes it was my upper jaw, then it was my lower jaw.

I had a check-up two weeks before getting the shot, and everything was fine. I have had one tooth filled and another had a crack and required a cap. This was within 2months after the shot. I have never had my teeth to hurt/gums to hurt until the Prolia shot. After reading the side affects, I am not the only one that has teeth problems afterwards. Hope this helps.
Lee