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Posted 9/1/2017 1:18 PM (GMT 0)
In all my travels and research over the past month plus a couple of times, i've heard the following and wanted to see if anyone has any more information on this. I kept hearing I'm way to young to have been diagnosed (40) with PC without a family history. I have no known family members who've had PC, so this just had me confused. While meeting with one Dr. (a medical oncologist) and one nurse yesterday in my pre-op appointments and going over family history, they both said oh that's why you have PC. My mother had breast cancer and they said there is a link between mothers with breast cancer and sons with PC. The nurse yesterday also said there is a reverse link which suggests daughters who have fathers with PC are more likely to have daughters who get breast cancer. Has anyone heard of this? Are there any studies that show this link? I'm just curious to find out the possible link. I guess i'd feel better knowing it was a genetic thing vs. something I could have prevented if that makes any sense.

Post Edited (Mrbaseball220) : 9/1/2017 7:30:28 AM (GMT-6)

Posted 9/1/2017 4:28 PM (GMT 0)
I have heard that theory but cannot point to any resource.
Posted 9/1/2017 6:13 PM (GMT 0)
Just to add to the mix

My mother had breast cancer, and of course I have PCa. No other history of PCa on either side of the family.
Posted 9/1/2017 6:15 PM (GMT 0)
I know there's a link if there are BRCA2 abnormalities in the family, but that's rare. This Swedish study found an association among family incidence of prostate, breast, ovarian, bladder,kidney cancers, leukemia and melanoma, perhaps indicating a genetic flaw that makes one susceptible to all of them. There was a negative association with lung and esophageal cancer.

/academic.oup.com/annonc/article-lookup/doi/10.1093/annonc/mdr056

Such effects are small, even for family history of prostate cancer. In white men, family risk is small, even though the relative risk is statistically significant . In Utah, PC incidence was 3.5% among white men with a family history of PC vs 1.5% in white men with no family history. So while the relative risk more than doubled, the absolute risk only increased by 2 percentage points.
Posted 9/1/2017 7:29 PM (GMT 0)
Fact: BRAC1 and BRAC2mgene mutations put men at higher risk for both prostate cancer AND breast cancer (although the chance of breast cancer in men goes from something like 1% to something like,3%.)

And those gene mutations put women at VERY much higher risk of not only breast cancer, but ovarian cancer.

I got this in. Conversation with a genetic counselor, who also gave it to us in writing.
Posted 9/6/2017 3:18 PM (GMT 0)
Yeah, it's a possible genetic link more than anything. My mom had BC as well (and also kidney cancer) and my father had PC in his late 60's. She's dead now and he's fine and living well (84).

I had all my genes tested over the past couple years and i have NO anomalies. And as my mother is dead I can't do a test no her (well, maybe I actually could, hmm.)

Anyway, as you have had PC you should probably at some point in the future talk with a genetic counselor or a very qualified doctor about what you MIGHT be at risk for and what you might consider doing to alter or change behavior.

I have been reading quite a lot of advanced research lately about the relationship between men who are high estrogen and prostate cancer incidence. It's much higher than the standard for men in general. Oddly, one thinks that it was/could be high TESTOSTERONE, but what it appears to be is that high test LEADS to actually high ESTROGENS and that is what leads to higher PCa.

So, trying to reduce things that are estrogenic in ones environment and diet could be positives to avoid PCa for men who don't already have it.
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