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Prostate Cancer
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Posted 1/18/2018 1:21 AM (GMT 0)
What are the thoughts on the ConfirmMDX test? I talked to my uro today and the rep for this company says they can test my biopsy samples for cancer potential. It's not going to cost me anything as they are going to include it as part of their local trials.
Posted 1/18/2018 7:56 AM (GMT 0)
Free is an excellent price, and it may give you some peace of mind to confirm that your negative biopsies were indeed true negatives (with 90% assurance).

Here's some info about it from the validation study:
/www.ncbi.nlm.nih.gov/pmc/articles/PMC4337855/

The downside is that an "abnormal" reading doesn't necessarily mean that there is any cancer hiding in the prostate, just that there is heightened risk of it. In the following study, 5 of the 138 patients got an "abnormal" reading, but none of them were positive on a repeat biopsy:

/www.ncbi.nlm.nih.gov/pmc/articles/PMC4070628/

It also does not distinguish cancer aggressiveness, as some genetic tests do - a GS6 gives off the same epigenetic markers as a GS10.
Posted 1/20/2018 1:57 PM (GMT 0)
Thanks Tall Allen, that was really helpful. I'm learning a lot about what is out there from this site and it's good to know there are others in similar situations. Regardless, it is tough to have such a high PSA number with no answer or direction.
Posted 1/20/2018 2:58 PM (GMT 0)
Not saying you have this, but I remember another member having had 10 biopsies before PC was located.

Turns out he had a transition zone tumor. A steady rise over time in PSA is one indication that there is a tumor in there somewhere. Other causes of PSA tend to be erratic, up and down

At the time, three or more years ago a Multiparametric MRI at 3 T was how it was located. Not sure what else is available now.
Posted 2/21/2018 10:43 PM (GMT 0)
The doctor called with the results today. There was no indication of cancer from this test. I've got a follow-up and another PSA test in about a month.
Posted 2/21/2018 10:46 PM (GMT 0)
That is very comforting news! 90% confidence in the result is pretty impressive.
Posted 2/26/2018 12:04 AM (GMT 0)
Pretty happy too at this point. Just have no idea what's causing the high PSA and the suspect MRI now.
Posted 3/21/2018 10:16 AM (GMT 0)
Just met with the urologist and PSA back down to 12.2 and DRE was normal. We are going to repeat at 3 month intervals and then plan on another MRI later this year to see if there are any changes. I read the MRI results and my prostate is 49 grams.
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