Since diabetes and the higher insulin levels that go with it are associated with worse outcomes for many(most?) cancers, including high risk PC, and many other serious health concerns, diabetes and pre diabetes is an oft voiced concern of several of us PC patients, and of course heart disease patients. Not to forget nephropathy, Alzheimer's and a long list of other patients. Diabetes and insulin resistance is like the gift that keeps on giving when it comes to promoting many different miseries.
In this study out of Iran, even though they used the somewhat strange(seems to me) approach of giving a mega dose of 50,000 IUs every 2 weeks rather than something closer to what plenty of sunshine would provide every day(could such huge repeated megadoses actually be harmful in some way?), they had pretty good results, n an area not often thought to be associated with Vitamin D.
They gave this dose to 30 diabetic foot ulcer patients(the type of thing that sometimes leads to tragic amputations) while the other 30 got placebo. After 12 weeks, the reductions in width, length and depth of the ulcers were about
twice as great in the Vitamin D group compared to placebo. In addition, serum insulin dropped by minus 3.4 vs an increase of +2.8 in the placebo, insulin resistance dropped minus 1.5 vs a +1.7 increase with placebo, LDL cholesterol dropped minus 17 vs + 2.2 increase, HDL improved, as well as CRP, all improved compared with Placebo.
/www.sciencedirect.com/science/article/pii/S1056872716302203Somebody said...
Conclusions
Overall, vitamin D supplementation for 12 weeks among patients with DFU had beneficial effects on glucose homeostasis, total-, LDL-, total-/HDL-cholesterol, ESR, hs-CRP and MDA levels. In addition, vitamin D may have played an indirect role in wound healing due to its effect on improved glycemic control.
Of course, some of us always wonder if any study is truly free of bias and can be trusted. Can this one? I don't know.
Post Edited (BillyBob@388) : 7/22/2018 10:28:04 PM (GMT-6)