what doesn't kill cancer makes it stronger ? Cancer Stem Cells(CNC) and HIF

this could be sensitive topic but thought would share some of my readings as it may be relevant.

1. Cancer Stem Cells and how they make cancer more resistant if it survives radiation

med.stanford.edu/news/all-news/2009/02/source-of-cancer-stem-cells-resistance-to-radiation-discovered-at-stanford.html

2. HIF

/www.webmd.com/cancer/news/20080610/treatment-can-make-cancer-stronger#1

The role of cancer stem cells in prostate cancer is still investigational. They have not been found to be part of all prostate tumors; at least, if they are there they are small and not very numerous.I don't know if dose escalation or extreme hypofractionation (SBRT) kills them, but that is certainly a possibility.

As for hypoxia conferring radio-resistance, that has driven many of the methods now employed (especially fractionation). One simple fix is to increase exercise:

/pcnrv.blogspot.com/2017/12/exercise-may-make-radiation-more.html

Some think that hyperthermia may assist:

/pcnrv.blogspot.com/2018/01/hyperthermia-and-radiation.html

There is are investigational MRI and PET scans that may be able to find hypoxic tumors, called BOLD MRI and 18F-MISO PET