Here are some studies/articles I see online:
(1)
from Catalona (from 2003, not sure??):
"We found that the tumor volume estimate is an independent predictor of possible cancer progression (recurrence) after a radical prostatectomy (RP) in patients with organ-confined prostate cancer."
drcatalona.com/quest/quest_winter03_2.asp(2)
from World Journal of Men's Health:
"Tumor-prostate ratio, rather than tumor volume, should be regarded as a significant risk factor for biochemical recurrence."
/www.ncbi.nlm.nih.gov/pmc/articles/PMC4999485/(3)
from International Journal of Molecular Sciences:
"Both tumor volume and PHI were statistically significant predictors of a biochemical recurrence"
/pdfs.semanticscholar.org/76ea/b1e5549bf0cfa259426437971895b83d354a.pdf(4)
from Stanford Health Care in 103rd Annual Meeting of the American-Urological-Association:
"In univariate analysis, both tumor volume (P<0.001) and percent cancer (P<0.001) significantly correlated with biochemical recurrence. Since they are highly correlated, they did not predict outcome independently when included in the same model; however, both were highly predictive for biochemical recurrence in separate multivariate models (P=0.01 for both). Both also correlated with cancer specific survival as single variables; however, in separate multivariate models, only tumor volume (P=0.03) predicted death, while percent cancer did not (P=0.09).Tumor volume and percent cancer are independent predictors of recurrence after radical prostatectomy. However, in our series, tumor volume predicted cancer specific death better than percent cancer. Therefore, accurate determination of tumor volume, along with other accepted pathologic indices, is sufficient and preferred over percent cancer for prognostication after radical prostatectomy."
/stanfordhealthcare.org/publications/858/85850.htmlHope this helps--it's a start, anyway...
Robert