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Zytiga side effects - Switch to Xtandi?

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Posted 10/2/2018 11:03 PM (GMT 0)
My PSA was at Nadir of 0.7 Went on Zytiga. Four weeks later PSA 0.2 but liver enzymes very high. Told to stop for two weeks.

Here's the thing. I was mild - moderate fatigued on Zytiga, had some brain fog, and have some side effects from the Prednisone.

I know Xtandi supposedly comes with fatigue and the side effects generally sound worse than Zytiga.

I figure everyone responds differently and I ought to try Xtandi rather than resume Zytiga even if my liver enzymes come under control.

Any one with experience with these medications? Some say Xtandi: No problem; Others: It was awful

I do know that at NIH they prefer Xtandi on account of the prednisone required with Zytiga. Other Dr's have said 5mg no big deal. I do know I'm having some reaction to the prednisone.

Any thoughts folks.
Posted 10/3/2018 1:54 AM (GMT 0)
I took zytiga for 7 months with no problems and then my liver numbers went haywire. I went off for 7 weeks and restarted at 750 mg. First test and liver numbers were back up. I reduced dose to 500 mg. Next test the liver numbers were back to normal. This Friday is my big test to see liver numbers and PSA. I'm hoping to stay on zytiga b/c I went to zero. All the side effects got better in time for me. I'd stick with zytiga if your liver allows.
Posted 10/3/2018 1:58 PM (GMT 0)
More fatigue for me while on Xtandi. I don't miss prednisone at all.
Michael
Posted 10/3/2018 3:23 PM (GMT 0)

Hello ~

Sometimes, they can lessen the dosage of ZYTIGA, when the situation warrants it.

My oncologist has me do lab work, every four weeks, to make sure everything is staying on track with ZYTIGA.

I have been on ZYTIGA now for nearly 40 months. We have members here who have been on ZYTIGA just a few months, and others who have been on ZYTIGA for much longer.

I plan to stay on ZYTIGA as long as I possibly can ... I even stayed on it this past spring, during nine solid weeks of radiation. ZYTIGA continues to help me ...

A couple of bits of advice, no matter what ...

To combat the feelings of fatigue ... a daily walk can really help boost energy levels. Stay consistent ... if the weather is rainy or inclement, find an indoor location for walking ... a shopping mall, a gym, a recreation center ... I even know of larger churches and schools that allow people to walk inside.

Also --- along with my ZYTIGA pills, which I take first thing in the morning --- it's essential to drink plenty of water along with the pills --- it helps combat any feelings of nausea that may ensue if you don't drink enough water with the pills.

One morning, I was in a rush, and "wolfed" the ZYTIGA tablets ... within an hour, I had the dry heaves, because I neglected to slow down and drink some water before, during, and AFTER I had taken each of the four ZYTIGA tablets. Lesson learned ! Has never happened again since the day I learned my lesson !

Wishing you the very best ~
CYCLONE ~ Iowa State University
Posted 10/3/2018 11:57 PM (GMT 0)
A couple of you have referred to the side effects of the prednisone. Would you mind telling me a little about what those were?

To 60 Michael. You say : "More fatigue for me while on Xtandi. I don't miss prednisone at all.
Michael"

So, on balance, which was worse?

How bad was the fatigue with Xtandi. All day blah? Tired at 5:00 p.m.? And, per my above question to the group -- what was it the prednisone did that you're glad to be rid of it.
Posted 10/4/2018 1:23 AM (GMT 0)
I don't think the prednisone does anything to me.(other than replace the stuff Zytiga kills in the adrenals).
It is the Lupron & Zytiga that give me the fatigue. Example: last night I went to bed at 10:30. I'm usually up at 6/6:15 but couldn't get up this morning. Dragged myself out of bed at 8:30. Had a foggy feeling most of the day until about 3 and then back to ok. I expect to be up and exercising at 6:30 tomorrow. Bottom line: everyone has a little different reaction. Another example: I don't take a lot of water with Zytiga and have never had a problem.
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