Mice cured (once again)

Interesting entry in "prostate new"
https://prostatecancerinfolink.net/2019/04/05/curing-mice-with-prostate-cancer/
Comments and discussion are also interesting. Sitemaster gives a plausable explanation of why checkpoint inhibitors like Keytruda do not work well for PCa. This new research line tries to find an alternative for them and it seems it succeeded (for mice, of course).
But everything suggesting that new efficient treatments may be around the corner is welcome to start the week, even if it is not so exactly that way.

Informative article below on some reasons why results from animal studies don't always translate into the same results for human studies.

From the article:

"If you have cancer and you are a mouse, we can take good care of you."

"... of the most-cited animal studies in prestigious scientific journals, such as Nature and Cell, only 37% were replicated in subsequent human randomised trials and 18% were contradicted in human trials."

"... the results of animal and human trials disagreed half the time."

"But far more problematic is a drug that seems safe in animal trials, but turns out to be unsafe in humans ... thalidomide (a drug to treat morning sickness) does not cause birth defects when given to pregnant rats and mice, but in humans it caused an international epidemic of birth defects."

"So, why do human and animal drug trials sometimes disagree so spectacularly? It boils down to the way the body absorbs and processes the drug and the way the drug affects the body."

(And here's something from the article that's OT, but you should definitely be aware of it if you own a dog):

"Chocolate is very toxic for dogs as their livers can’t break down some of chocolate’s components."

http://theconversation.com/of-mice-and-men-why-animal-trial-results-dont-always-translate-to-humans-73354

Here's a very interesting video giving a brief history of how mice and rats came to be the primary lab test animals, and reasons why they are especially suitable for this purpose:

https://www.youtube.com/watch?v=dsqwntayydg