My take is this: If they found a bunch of G4's there was likely a G5 or 2 somewhere that did not get seen. It is commonly believed that a PCa 'stem cell' (G5) lives about
2 and 1/2 years. It is also commonly believed that they need testosterone to reproduce and to move from where they are. Thus, if you get put on leuprolide chemo, many docs want to keep you on that until all of the cancer cells are (maybe) dead from the other treatments and there are no new PCa cells. This works better in theory than in real life.
I was on leuprolide chemo for 2 and 1/2 years. It took another 2 and 1/2 years for me to recover to my new normal. I too am (somewhat) reassured by the knowledge that there are other treatments out there in the hope to further 'kick the can down the road'.
Some of the weight gain is water weight gain due to the kidneys not removing enough water from the bloodstream due to the complete shutdown of the hypothalamus and pituitary by the Lupron. Some of the weight gain is due to a lowered base metabolic rate for the same reason. Lack of human growth hormone, HGH, is to blame for the loss of normal brain maintenance, loss of muscle mass, and the gain of fat. Same cause.
IMHO, attempting to live as healthy a lifestyle as possible is not just a good way to get at least some control over this condition, it helps in dealing with the emotional aspects as well.