Obesity at diagnosis and prostate cancer prognosis and recurrence risk following primary treatment

In this study, the correlation between BMI—18.5- < 25, 25- < 30, 30- < 35, ≥ 35 kg/m2)— and prognostic risk at diagnosis was examined; the concordance between prognostic risk assessed at diagnostic biopsy vs pathologic risk assessed at surgery across BMI categories was compared; and the correlation between obesity and prostate cancer recurrence and all-cause death was determined. Among men enrolled in CaPSURE (n = 5,200) who underwent radical prostatectomy between 1995-2017, 685 experienced recurrence during a median follow-up of 4.5 years. Observations revealed that BMI is correlated with recurrence following adjustment for disease severity using diagnostic factors (HRvery obese = 1.7); when adjusting for disease severity factors obtained at surgery, this association disappeared. The conflicting evidence regarding obesity's influence on prostate cancer progression may partially be related to residual confounding. In larger men, the possibility of a complicated assessment of T-stage via digital rectal exam may influence clinical treatment decisions. Researchers observed a strong association with all-cause mortality indicating healthier BMI at diagnosis to be related to improved overall survival.

What I found interesting only 13% had BCR which is good! I know we have lots of discussions on the forum about diet and this study kinda backs up what a lot of us believe. PCA affects both skinny and fat guys doesn't discrimate but the people who do have a lower BMI seem to have a better overall survival rate which is true basically for everyone regardless if a person has cancer or not. Before WWII most people ate organic food, including meats and vegetables, Almost everyone had low BMI's but the average life span in 1930 was 60 now it's 78. A lot of this can be attributed to the great advances in medicine, the lack of plaques, and no world wars. So I still believe if a person does try to keep a balance in life with diet, work, exercise, love and enjoy our families and friends that's about the best we can do no matter what is thrown at us! We just had a 23 yr old girl who's life was snuffed out on a ATV accident at our local offroad park on Sunday. Just out with a bunch of people having fun and now she's gone. My wife and I were sitting watching the ambulances, police vehicles, fire trucks and helicopters going to the scene which is only about a mile from our house and we knew it wasn't good. When we heard the sad news we were just so thankful that we had just sent our grandson home safe and sound after enjoying 2 weeks with him. As my wife and I get older we have come to enjoy the priceless moments more and more and worry less about a lot of other things!! I'm gonna quit rambling. Hope everyone has a great day!

Larry

I should point out that there is a difference between a high BMI and obesity. Also, there is a difference between correlation and causation.

All humans drink water, all humans die, so drinking water causes death? No, rather, they are correlated.

Of course, I encourage all of us to be as health conscious as we possibly can.

Then there is TOFI, thin on the outside fat on the inside with low BMI. https://www.ncbi.nlm.nih.gov/pubmed/9588440

Skypilot56 said...
Hey I got high BMI but I just blame it on Lupron!!! LOL 🤣😜😂


Larry

Aint that the truth!