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How Quickly Lupron Kills Hormone-sensitive prostate Cancer

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Posted 5/18/2020 12:36 AM (GMT 0)
When you are on Lupron Testosterone drops and lack of Testosterone kills hormone-sensitive prostate cancer cells. How long should Lupron to kill all the hormone-sensitive prostate cancer cells?
Posted 5/18/2020 1:32 AM (GMT 0)
Kill all? I don't think that has been invented yet. My PSA went from .28 to .03 weeks after I had my first shot.
Posted 5/18/2020 1:58 AM (GMT 0)
I wish it did kill PC.
Posted 5/18/2020 2:04 AM (GMT 0)

Keep collecting stories ...

Here's mine ...

Diagnosed with PSA over 100 ... got a LUPRON shot immediately upon diagnosis, following biopsy.

After one month on LUPRON and Casodex, my PSA tumbled down to single digits.

That was a MEMORABLE day! Celebrated at my favorite Midwestern barbecue restaurant ... all hickory smoked ... it's the best.

The second month, my PSA tumbled down to decimals ... less than 1.00.

THAT was a very good day! Back to the barbecue restaurant that night, to celebrate ...

Each case is different ---- I know when posting it truly helps to get a range of responses.

Sending my best,
Cyclone - # Iowa State University
Posted 5/18/2020 11:25 AM (GMT 0)
The theory is that leuprolide acetate chemotherapy (Lupron, Eligard etc) prevents hormone sensitive PCa cells from reproducing or moving (metastasizing) as long those chemicals are in your blood stream. The belief is that regular PCa cells live for about 2 & 1/2 years, so hypothetically, if you are on leuprolide chemo for 2 years or so all of those PCa cells will 'age out', die off and you will be cured. *applause*

Unfortunately, the reality is somewhat different than that. Some PCa cancer stem cells don't really care much about testosterone and keep on keeping on doing their thing regardless of having no testosterone. That leads to 'biochemical failure', a return of rising PSA levels and the need to then move on to other chemicals and/or treatments.

'ADT' kicks the can down the road a ways but is not a cure for prostate cancer, sorry.
Posted 5/18/2020 2:13 PM (GMT 0)
Hmm, I was on Lupron for 2 1/2 years, my PSA was undetectable that whole time. Then we decided to take a break from it, my PSA began to rise rather dramatically after about a year.

So, the time for complete apoptosis for PCa to occur is still undetermined.

I wish it were!!
Posted 5/18/2020 7:30 PM (GMT 0)
Me too, same thing. sad
Posted 5/19/2020 12:41 AM (GMT 0)
I've been off Degarelix for just over a year. The first six months PSA was undetectable <0.02. It is now 0.92 and doubling at 2 to 3 months. I'll be starting another round of ADT soon unless the PET scan in two weeks shows something that can be zapped into submission for a while longer.
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