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PSA density, what is it

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Posted 9/7/2020 10:25 PM (GMT 0)
Is it best to have a low number or a high.
Posted 9/7/2020 10:49 PM (GMT 0)
The number should be below .15

Anything above that is suspicious for prostate cancer. PSADensity is more important than PSA in Johns Hopkins Active Surveillance program.
Posted 9/8/2020 12:50 AM (GMT 0)

62gal said...
Is it best to have a low number or a high.

The principle behind PSA density is that malignant cells usually put out more PSA than healthy cells, which is why a rising PSA is a warning indicator. However, healthy prostates vary quite a lot since the prostate grows some with age and even more so if there is any BPH.

Since a larger prostate will put out twice as much PSA than one half its volume, PSA density is used to to calculate the PSA per cc of prostate tissue. You divide the PSA value (in ng/mL) by the volume of the prostate gland in cc or mL. (Prostate volume is estimated by either an MRI or by ultrasound.)

So yes, lower is better.

Djin
Posted 9/8/2020 1:02 AM (GMT 0)
Then .08 ng/ml/cc should be OK with an enlarged prostate.

Post Edited (62gal) : 9/7/2020 8:57:11 PM (GMT-6)

Posted 9/8/2020 3:25 PM (GMT 0)
As far as PSA Density goes, yes that would be a good number. As the prostate gets bigger, if the PSA stays the same, the Density will get lower. I feel I'm going through that myself.
Posted 9/8/2020 7:27 PM (GMT 0)
It is a piece of information but it does not mean you are “ok” if that means no possible problems. Like so many things with PCa, there are lots of bad indicators but very few that mean you are “ok”. Hope I did not misunderstand your use of “OK”.
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