Free PSA% test after treatment

Following the % free PSA after RT for primary treatment is new to me. Is it possible the test including free PSA was ordered in error? If it was your PCP, that would be my guess.

Free PSA Ratio as a Predictor of Adverse Outcomes after Curative-Intent External Beam Radiation Therapy for Prostate Cancer: A Novel Application of an "Old" Biomarker (2018)

"Conclusion
This study suggests that a fPSA ratio >=0.15 in the setting of post curative-intent EBRT denotes a more aggressive disease, reflected in higher rates of metastasis and CRPC. Our findings suggest a reversal in the significance of fPSA ratio in the post treatment state, and a potential novel role for this widely available and low-cost biomarker."

Djin

Clearly you and I are both far past the PCa diagnosis stage . The study I linked was looking at whether free PSA might prove useful in prognosticating. In any case your free PSA of 10% is below their 15% threshold of concern anyway (this is the same ratio of free PSA to total PSA that is used for undiagnosed men). I pointed it out more as a curiosity -- I doubt many Forum brothers here have had their post-RT free PSA measured intentionally.

The commonly used definition of BCR (a concerning PSA rise) after primary RT is the Phoenix definition: a (total) PSA of 2.0 above your post-RT nadir. But others with RT experience can give you more details.

Djin

Post Edited (DjinTonic) : 2/25/2021 7:42:05 PM (GMT-7)

Good to hear from you again, Artist Mark.

Any uptick in PSA leads all of us fellows to worry.

Stay vigilant, and sounds like you are staying proactive, with a message placed with your radiation oncologist.

Just wanted to extend a message of greeting, and let us know how you're faring.

Hopefully, your oncologist will have some insight and reassurance. Glad to see your post, here on the forum!

Handshake, from across the miles ~~~
CYCLONE ~~~ # Iowa State University