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Pluvicto / LU-177 Chapter 2

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Posted 5/3/2023 5:49 PM (GMT 0)
As I've documented here in the past, I've been blessed to have gotten LU-177 before FDA approval through a compassionate use program at UCLA. To recap that success, first treatment in August 2021, PSA 65, Sixth treatment in March 2022. PSA on 6/27/22 was 0.64.
Fast forward to today, where PSA is now 214. For a couple months it was more than doubling each month. Now the rate is more like 50% per month. I have FINALLY switched to Medicare from my work coverage (which denied another regimen of Pluvicto), and have just been approved and scheduled for six more treatments here in SoCal. !! Very happy, relieved, excited, blessed.
Many of you have wondered IF a second round of Pluvicto was possible--and IF it would be effective. Well, it IS possible, including insurance coverage, and I'll keep you all posted on its effectiveness. First treatment is May 15.
Thanks for everyone's support throughout this journey.!! Steve
Posted 5/3/2023 5:56 PM (GMT 0)
Steve,
Glad you got it sorted out. I'm hoping for good things!
Posted 5/3/2023 7:23 PM (GMT 0)
Good news. Here's hoping round 2 has great success.
Posted 5/3/2023 7:38 PM (GMT 0)
Great news. Keep us posted.
Posted 5/3/2023 7:45 PM (GMT 0)
Steve, Thanks for starting this thread and keeping us informed. Wish you all success…. Bill
Posted 5/3/2023 8:27 PM (GMT 0)
Wishing you success with the next round of Pluvicto. Good news! DH has had 3 of 6 scheduled treatments so far with success, and we had wondered if additional treatments would be effective (and available) if he needs it in the future. Please let us know how your are doing with the next round.
Posted 5/4/2023 1:08 AM (GMT 0)
Hello, Steve55777 ~

I had been thinking of you, so your update is most welcome.

I'm truly THANKFUL that you have received approval for the hoped-for second series of PLUVICTO (Lutetium-177) treatments.

This is truly trailblazing, and I feel a debt of gratitude to you and others for documenting your experiences here. It represents the wave of the future, and a way of battling prostate cancer in a completely new way.

I'm going to mark May 15th on my calendar, and will send supportive thoughts your way when your treatments commence.

You are a loyal compadre of ours here. We're rallied around you, as you set your sights on this additional series of PLUVICTO treatments!

Handshake, camaraderie, & fellowship ~ from "one battle brother to another" ~~~

CYCLONE ~ # Iowa State University
Posted 5/14/2023 1:22 PM (GMT 0)
Hello, Steve55777 ~

I will be thinking of you this week, as your second series of PLUVICTO treatments begins (Lutetium-177).

Here's to treatment success and may it all go well!

Handshake, encouragement, fellowship ~
CYCLONE ~ # Iowa State University
Posted 5/14/2023 1:42 PM (GMT 0)
Steve55777,
I pray that all goes well this week as you enter your second series of Pluvicto treatments this week.

Ron (Boomer)
Posted 5/14/2023 2:59 PM (GMT 0)
Thanks so much. I really appreciate your support. Steve
Posted 5/14/2023 6:22 PM (GMT 0)
Prayers and best wishes and thanks for sharing. Cyclone said it best. Thanks again for keeping us informed.
Posted 5/15/2023 8:34 PM (GMT 0)
Well, I just had Pluvicto Round 2, Treatment #1 this morning. That's technically Pluvito/LU-177 treatment #7 for me. While it'll be awhile until I see a new PSA test, I can tell you that the administration of the Pluvicto drug has come A LONG WAY in the past 18 months (and since FDA approved). What was once a 2 1/2-hour process (at UCLA) from late 2021 to 2022, I had a 9 AM appointment at Hoag in Irvine, and was out the door by 9:30!

Those of you who read my post "LU-177 My Next Treatment" may recall the process being one of an IV system which saw saline dripped into the LU-177 canister, then out of the canister to my arm. That took about 30-40 minutes of actual infusion time, but with another 40 minutes before and after for fluids, preparation, etc. Now, a metal case 15" x 7 x 7" has a single IV tube going into my arm. It takes about 12 minutes. Then they flush the tube to assure all the Pluvicto gets into you, then they remove the IV. You wait 10 minutes, get discharge instruction, and you are out the door.

It's been 4 1/2 hours since my treatment and I feel nothing. Not even tired (yet). Took my laxatives (from the previous LU-177 lessons learned), and I'm in my home office ready for a Zoom meeting. It is unbelievable. Now, may it go after all the PC mets! Will keep you posted, brothers & sisters. Thanks - Steve
Posted 5/15/2023 9:29 PM (GMT 0)
<<Now, may it go after all the PC mets>>

Steve,
Thanks for your posts. I'm hoping the Pluvicto gets at it hard!
Posted 5/16/2023 12:05 AM (GMT 0)
Was thinking of you today, Steve55777, knowing today was your treatment day.

Honestly, that's incredible ~ that this new treatment has already been refined ~ in terms of administration to patients.

Your first-hand account is powerful ~ because you have ALREADY experienced the refinement in receiving the dose. Incredible, really!

In a myriad number of ways, PLUVICTO seems to truly represent a very new way of treating prostate cancer. What a welcomed addition to the treatment arsenal.

A fellow diagnosed a couple of decades ago might have been told, "Well, we have a couple of treatments we can possibly try."

A fellow diagnosed today might well be told, "We have a variety of viable treatment options available for you."

I bet today's treatment is already AT WORK tonight, in your case.

I was SO thankful when you found out that you could pursue a second series of treatments.

We're rallied around you, sending our collective support, Steve55777!

With all my best ~
CYCLONE ~ # Iowa State University
Posted 5/16/2023 2:24 AM (GMT 0)
Blazing the trail, Steve. You’ve got my prayers…full speed ahead!
Posted 5/16/2023 4:25 PM (GMT 0)
🤞
Posted 5/16/2023 5:55 PM (GMT 0)
Steve, I remember asking you to describe the process during your first treatment. You described in great detail everything you had to go through. I am very happy they have considerably shortened that process.
As always, wishing you best this go around.
Jack
Posted 5/18/2023 8:33 PM (GMT 0)
Steve, Thank you for the informative and useful update. Wishing you well… Bill
Posted 5/27/2023 3:35 PM (GMT 0)
OK. Preliminary results are in--and they look great!

To provide context, my PSA has been rising the past 5 months by an average of 85% per month(!). My previous month's PSA was 214. Assuming an increase of 85%, this month's should be 395. So, 3 weeks after that test the PSA "should have been" 297. 3 Weeks after that test showing 214, I had my first Pluvicto/LU-177 treatment (actually my seventh treatment for those keeping score). One week later (when technically my PSA should have been 297), it was 193!!!

This means, Pluvicto treatment #1, Round 2, IS WORKING! After ONLY 1 WEEK!

I am so blessed. Wanted to share right away. Will keep you posted on the next treatments and PSA tests.
Steve
Posted 5/27/2023 3:50 PM (GMT 0)
That is fantastic, Steve.
Michael
Posted 5/27/2023 4:15 PM (GMT 0)
Steve,
I had trouble deciphering your context, but the Pluvicto evidently is working. That's what matters. I couldn't be more pleased for you! It would be interesting to know how many guys have had a 2nd series of Pluvicto. Maybe you're one of the first.

Congratulations, keep it going, and have a great holiday weekend!
Posted 5/27/2023 4:39 PM (GMT 0)
Steve, have you seen a 70 year old do a back flip? Neither have I, but if I could, I would do one for you. Fantastic news and I can’t wait to see your future great results.
As always my best wishes to you,
Jack
Posted 5/27/2023 5:31 PM (GMT 0)
Steve, SIMPLY GREAT. Really happy for you. You may well be the first American to receive a second course. Best wishes…. Bill
Posted 5/27/2023 7:11 PM (GMT 0)
Steve,

That sounds great! My thoughts and prayers continue to be with you, as well as everyone fighting PCa.

Ron (Boomer)
Posted 5/27/2023 8:11 PM (GMT 0)
Thanks guys. Sorry for confusing context part. I wrestled with that. Bottom line is when I had the treatment my PSA was estimated to be 297. A week after that treatment it was 193. That means it’s working! Really well I’d say!
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