1st Pluvicto treatment done — how well does it work?

Been a while, so thought I’d provide an update. After six rounds of docetaxel + Carboplatin, which ended February 28, my tumors appeared to have shrunk a bit, and reduced their intensity (SUV), but not as dramatically as my Mayo doc would have liked to see. He put me in for Pluvicto and I had my first treatment last Thursday, 5/25. The treatment was preceded by “education” meetings and blood work, and followed up 24 hours later with a scan to see if the radioisotopes had hit their PCa targets, which they had. The scans also revealed no new metastases, which I found encouraging. I traveled back to Boston on Friday, and felt great until Monday when I got walloped with fatigue, some nausea and aches/pains primarily in my thighs and hips. Spent the day in bed, under the covers! I improved somewhat today and hope to be back 100% tomorrow. I will receive six Pluvicto treatments, one every six weeks, ending in December. When I go for my third treatment in August, they will do another PSMA Pet scan and see what kind of impact the Pluvicto is having,. Fingers crossed. I am still getting my quarterly Lupron, and taking Nubeqa. My PSA is undetectable. I would love to hear from people who have been through Pluvicto, and how well (or not) it worked to kill the cancer? I know it will eventually come back, but has it bought people time? From what I’ve read and seen, it works really well on about a third of the patients — the other two-thirds, not so much… Sending healing thoughts and prayers.

You bet. I will update as I get more information.

Thanks for the assist Susie. I’ve now been through my seventh pluvicto treatment. See my post about LU-177 My next Treatment which chronicles my first round of treatments. Amazing success. But you say your PSA is undetectable??? How did you get approval for pluvicto? Any way. Best of luck!!

I've had low to undetectable PSA since diagnosis in 2019. It's a sign, I believe, of a more aggressive cancer. I had a biopsy done in 2022 and it came back as adenocarcinoma, but my doctor says it has neuroendocrine qualities. As for Pluvicto, the criteria has more to do, I believe, with the PSMA rating of the cancer (mine is #3, the brightest), and whether one has been on or through chemo (I did six rounds of docetaxel + Carboplatin) and/or a second generation ADT (I'm on Nubeqa, darolutimide). So, I'm hoping to get a good response from
Pluvicto, but am a realist. I always tend to look ahead, worst-case scenario, to understand what's next if this doesn't do the job. I'm not sure, and I'd love to hear from people with far more knowledge than I have. I'm also really interested in what's happening in Germany and Australia (and any other country that's ahead of USA on treatments...) to assess whether I should investigate travel for treatment. Anyways, that's where I am now. I read through both of your threads a few days ago and was so happy to hear you had been approved for round #2 -- and I'm curious to hear what your next PSMA Pet scan looks like. While most people celebrate a drop in PSA, my cancer doesn't have that marker so I go completely by scans!

YES, we live on the Vineyard year-round. If you're coming to the island this summer let me know and would love to get together and swap stories!

Can you direct message me on this site? I’m not sure how to do it. I’m off island through Sunday. How about a little coffee/breakfast at Black Dog Cafe on State Road 8 am Wednesday?

Great! See you there…8 am or 9 am ( I had suggested 8 but can work w 9).

That is amazingly cool.
Michael

Island boy: tomorrow at 9, my wife and I will be there. I’ll have a Pebble Beach golf cap on.

Great meeting place guys. My wife and I will be on the Vineyard end of August… Bill

Well, after I had to cancel a couple times, Island Boy and I finally met on our island today. Sure is great to meet a fellow brother/warrior in person to discover the similarities and differences on our paths on this journey. Looks like we're on very similar Pluvicto schedules as we've each had our first tx and each get #2 in the next couple of weeks. (This is really #7 for me after completing six LU-177 treatments a couple years ago). We will closely compare our experiences and report to our forum brothers and sisters when we have meaningful info. Thanks all. - Steve

So glad you fellows got together!

You're both blazing a new trail with PLUVICTO treatments.

It's tremendous that this treatment is now available & it's great that you are documenting your experiences here!

My best to you both!

C-Y-C-L-O-N-E ~ # ISU

Islandboy said...
Hoping for some good news.

Us too, shipmate.

Was up in Newport, RI this week for work, and thought of you guys not too far off on your island. Is a nice corner of America.