Yes, it is possible to be celiac with IgA positive but IgG negative.
The upper endoscopy with biopsies will confirm one way or the other.
Upper endoscopy with biopsies is the gold standard to confirm diagnosis, and it's standard procedure when the TTG IgA blood test is positive.
The TTG IgA test is most commonly given and has very good specificity. My understanding is that the IgG test is used less often, mostly in cases in which the patient has an IgA deficiency and could have false negatives on their TTG IgA results.
In other words, the IgA test is the one to use for most people. The IgG test is only valuable for a select subset of individuals.
Eating gluten right before the appointment wouldn't matter. It might have raised her values a little, but it wouldn't change a negative result to a positive unless she had been completely gluten free for several months up until that meal and has celiac.
You actually *want* the patient to be eating gluten in the days/weeks leading up to the testing, in order to avoid false negatives.
As for the procedure, it's quick and painless and just takes about
10 minutes. They'll sedate her right before they start, so she shouldn't feel a thing or remember a thing. She'll just wake up 20 minutes later, maybe with a little bit of an irritated throat and a bit groggy, but otherwise fine.
Good luck. It's actually a good thing the doc thought to check for celiac.
Post Edited (beave) : 7/21/2022 11:19:33 PM (GMT-7)