Annie76 - In the beginning of the nodule diagnosis, we tried Synthroid to shrink them, but it didn't work. I get a scan done every year to see if they are growing, and also every other year a biopsy; which I have to tell you is not fun - but worth knowing the results. I've had 3 done so far, and am due for another scan. New ones keep popping up. One is just a large cyst on the left side, but I have another nodule behind that one, so they have to go thru the cyst to biopsy the one behind it. I also have one on my ismus, and multiple ones on the right side. They don't both to check the small ones, they are of no concern.