I use Prodiem tabs one just before bed with enough water to get it all the way down...
I'm either allergic or non-responsive to traditional oral RX so I had no choice but to put my (HUGE) skeptisism aside and try the natural route (which I've been doing for about 5 yrs now)...
I use bee propolis, fibre supplement (which my GI urged me to take), omegas 3-6-9, probiotics called primadophilus reuteri (which aided my high cholesterol and severe lactose intolerance issues as well as vaginal health), vitamins A and C (I also take B12 but not to help with my CD symptoms directly), I drink chamomile tea and water (on occassion 100% fresh juice) exercise regularly with cardio and weights, have eliminated fast-foods, processed foods/beverages, animal fats, refined sugar and sugar substitutes/artificial sweetners from my diet.
I used to "go" 30+ times/day with bleeding, tons of mucus, horrible lower back pain and anywhere from semi-formed to mush to D...I now go 5 or less times a day, fully formed stools, no bleeding, no mucus, no pain...Most of the credit for this goes to the bee propolis and fibre supplements but the combination of all has brought me down to the level I'm presently at, not full remission as I still have issues with urgency and frequency as 5/day for me is not "normal" (one/day is)...but I'll take what I can get...My GI also encourages me to continue on this route, to him it doesn't matter that oral RX aren't helping me so long as something does, now that's a good GI.
I have crohn's colitis (CD affecting my colon) and have never been in full remission due to complications with perianal crohn's skin tags which is where my disease actually started (on the outside of my anus) and then moved inwards.
And here is a link from the CCFC...my GI answers questions in the "Ask the Doctor" portion which this link will take you directly to, just so happens a UCer posed your very same Q about new meds in the pipeline...
http://www.ccfc.ca/English/info/askdoctor.html
:)