Yup, it's the worst...I havae a love/hate relationship with Remicade. It's certainly made my life a heckuva lot more "liveable", & has enabled me to avoid surgery so far. But.... it's no miracle drug for me like it is for so many others! I get burned sometimes.... like "Why?!?!" And I know darn well that sooner or later, it'll really start to lose effectiveness, & then what? I try Humira, & stick with that as long as it lasts, & hope in the meantime they come up with something other than a TNF blocker! I don't find it frustrating so much as saddening. I think the fact that for UC, the TNF blockers are the "end of the line" drugs, so when they stop working, or don't work as well as they could, it's a HUGE letdown. Especially when you start off so promising, & feel so darn good, & think it'll be that way forever. BooHoo....