For what it's worth, I too have always been told that YES, definitely get a flu shot. Especially while on prednisone, & any/all immune suppressants, like Imuran & Remicade. The thing is this- you cannot get any live vaccines while on these meds- any inactive ones are fine. The flu shot is not live, the flu mist is live. I believe the shingles vaccine is live also, but I'm not %100 sure. My primary care doc recommended I get a pneumonia shot also, after I got over strep pneumonia last year. But I don't think I did get one- I honestly csan't remember. Doctors generally recommend inactive vaccines for immune-suppressed people. It's never been an issue with me re. Remicade infusions, the vaccinations.