Well, I know I orginally posed this question to most of you, but now I'm certain. As a spouse of someone on Humira, I am having an allergic reaction to it! It all started April 1st when my husband went in for his first dose of Humira. He received 4 injections. Well that night we slept together, and ever since then, I've been going through "hell" with hives and more specifically urticarial vasculitis. I've even been to the ER 3 times for help because the hives were so severe. So I just want to warn everyone, even spouses!!! We also slept together on the 15th and I broke out in hives again. I'm more medicated now so the hives weren't as bad, but I've been keeping a log of everything. My doctor's, the immunologist and my GI were both skeptical because it would be so rare and unlikey, but now I'm absolutley postive! After not sleeping with one another for a couple weeks my hives just about had disappeared. It was great. So we once again we decided to put my theory to the test, and we slept together on the 1st of May. The very next day...I broke out in hives again. Today they are like welts in some places. Just awful!! Not that I want to share my sex life with everyone, but I think it's very important to know that even spouses can have an allergic reaction to Humira. I'm calling my doctor in the morning, and I can't wait to tell her what has happened. Now I'm certain!!!!! So BEWARE!!!!! This is terrible, and nothing I would wish on my worst enemy! :)