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Methotrexate

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Ulcerative Colitis
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Posted 6/10/2009 2:22 AM (GMT 0)
Anyone try methotrexate for UC? Just started weekly injections yesterday.

....I've run through the Asacol, Rowasa, Imuran, Remicade options and for various reasons (pancreatitis, enzyme activity, intolerance)...they are all no good for me.

I know methotrexate is not labeled for use in UC or even Chron's, its a typical RA treatment, but I guess treatments between the various auto-immune diseases does overlap.

Posted 6/10/2009 10:45 AM (GMT 0)
i took methotrexate for my psoraisis a few years back and when i was on it, i got the worst flare of my entire life that lasted a painful hospital ridden year and half long flare.

was told it wasnt the methotrexate as they use that for crohns, but it is and was the only new and different thing i was on in ages and bam, UC like never before.

so im pretty much no help but for that little story.
Posted 6/11/2009 12:57 AM (GMT 0)
That's no good! I wonder if there is a correlation between it and your flare. I mean some people do worse on certain medications.

I have to be honest that I don't have much faith in it because its not widely used in UC and if it worked well then you would think it would be used more. It's also been around forever so it's not like it's a new drug that they are still extensively studying.

I've seen very little on this forum about it and UC. I guess I'll find out sooner or later if it's helping.
Posted 6/11/2009 3:16 AM (GMT 0)
i'm supposed to be starting that as well...can you tell me if it works out for you?
Posted 6/11/2009 3:08 PM (GMT 0)
I have used it for crohns, in fact it is the only med that has even half way worked. But the shots are usually used in those who get the lupus from the biologics. Also it is usually used in those that have not the "usual" crohns, it for those who are going well over 30 times a day.
Posted 6/12/2009 12:12 AM (GMT 0)
AM---I'll keep you upto date on if there is an improvement. I've been feeling ok (not great, but better) lately, which is definately due to the prednisone I'm on, but I'm already on a taper schedule with that, so once the dose on that starts getting lower we'll see if my flare comes back or if the MTX keeps it in check.


MMMNAVY--the biologics, (Remicade), where no good for me. First infusion was fine, but during the second one my whole body started shaking uncontrollably and I spiked a fever. The had to give me some Demerol to make the shaking start. On top of the reaction I had, there was no improvement after either infusion. So that's what brought us to MTX.
Posted 6/12/2009 3:41 AM (GMT 0)
That is definately a scary reaction! Mtx is a very common and older medication. It takes a couple months to get to theraputic level. But it worked pretty good for me.
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