Hi Amy,
Years ago my dr suggested that I take the rowasa enemas because there are less side effects than pills ( like stomach upset! ) and I was lucky some nights to keep it in an hour before I had an urge to go! You ask about feeling a sensation of the enema working? Well, there is no sensation to feel because the medicine doesn't cause a sensation so you're ok, don't worry because as long as you can keep it in through the night you are doing awesome! When you wake up and use the bathroom all the watery substance will come out before you have a bm, it is normal. I hope it works well for you, for some people it works wonderful and some it does not. As you get use to the enemas you will sleep better and become more comfortable after your body knows what to expect. Just like any medication, they take a while to see a difference. Keep your head up girl!