new phosphatidylcholine drug LT-02 in the not too distant future?

in response to: "it is difficult to treat the cause when we don't even know what the cause is."

well than why take any medicine at all if u feel that way!!! if we wait around for the greedy corporations to find the cause, we'll never feel better.

we DON'T know the cause, but we still use OTHER drugs such as remicade, imuran, asacol, enemas, etc. to treat UC. just because you don't know the cause doesn't mean you shouldn't try anything. if that were the case, no one would take any medicine and we'd all be so sick we'd just have to have our colons removed. there were studies done on pc and it showed a success rate. and it's sure better than taking the more toxic drugs that destroy our bodies. what's the harm? we need something to take to contol uc so as to try to lead a normal life.

"Ulcerative colitis patients can now live in the hope that an effective drug will be available to them in the not too distant future."

Unfortunately, because of our wonderful FDA protecting ourselves from ourselves it takes millions of dollars and many years to bring a drug to market.

 

"... only noteworthy side effect experienced by the patients was flatulence, which resulted from the special packaging material used."

I could but up with a little flatulence if it would mean no more flares. After all, could it smell worse than incontinence?

Post Edited (wodin) : 9/27/2010 12:30:47 PM (GMT-6)

What is really bothering me about retarded release PC is they put out the first patent in 1999 yes 1999 and they are still messing with it. It has taken this long to get this far and its is still not out and it is a natural product found in food
How many colons have to be lost before it comes out, my son lost his in 2000, it is starting to make me really upset with the
whole medical establishment.
old mike

sakiv46 said...
kate22, I haven't heard of this compound. But if the pharmacist believe that it can retard the absorption, there is no harm in trying it. I will be willing to buy from them.

 

It's Methyl Cellulose; WikiPedia has an article here. It's interesting that it was used in the movie GhostBusters as slime.

It can be purchased from Amazon.com here, and phosphatidylcholine can also be purchased from them here. Both are marketed as either food products or dietary supplement.

From the description of Methyl Cellulose, it looks an awful lot like Metamucil, and like Metamucil is used as both a stool softener and a diarrhea treatment.

The next question is how to formulate it, and at what dosage.

 

Post Edited (wodin) : 9/27/2010 5:44:50 PM (GMT-6)

Yes, EUDRAGIT® Polymers are targeted coatings designed to allow the active ingredients in your solid dosage form to perform during the passage of the human body. They, however, require industrial processes to formulate, and are not generally available to the public.

They would indeed be the superior delivery method, but until they can successfully navigate the regulatory and bureaucratic maze necessary in order to be approved by the FDA, they will not be available to people who desperately need a solution. Perhaps an adequate but less effective solution is possible.

I’m reminded of the old Klingon adage: The perfect is often the enemy of the good enough.

wodin said...
sakiv46 said...
kate22, I haven't heard of this compound. But if the pharmacist believe that it can retard the absorption, there is no harm in trying it. I will be willing to buy from them.




It's Methyl Cellulose; WikiPedia has an article here, and phosphatidylcholine can also be purchased from them here. Both are marketed as either food products or dietary supplement.
From the description of Methyl Cellulose, it looks an awful lot like Metamucil, and like Metamucil is used as both a stool softener and a diarrhea treatment.
The next question is how to formulate it, and at what dosage.

It sounded like we were close to a 'Guerrilla' drug here. Enteric coated capsules simply release their contents when the PH changes in the large bowel from that of the small bowel. This does not sound that difficult to accomplish.

There does seem to be a problem purchasing empty enteric coated capsules

"Do you carry 'enteric coated' capsules?
"Enteric coating" is a process which is done after a capsule has been filled, therefore it isn't possible to sell empty enteric-coated capsules."

www.cap-m-quik.com/faq.html

These folks can handle it but it looks expensive

/www.colorcon.com/products/coatings/enteric-delayed-release

Post Edited (aguywithuc) : 10/26/2010 11:11:12 PM (GMT-6)

I hate to be a party pooper (great cliche, eh?)..however, this is in Europe, and unless someone knows someone who can get this trial involved
with an american company, it will be several years before it gets here..it may get to Canada, and you can order it then....

My husband is considering making a delayed release pill with edible bees wax (we've used an herbal pill like this in the past made by an herbalist and it worked in the sense that it released in the colon). What would you guys use in the pill EXACtLY - I'm a little confused by what they are using. lechithin? ppc? phoschol?
Thanks!

Okay thanks Levi. We did try phoschol orally and it didn't do anything (it's pure ppc) and it was irritating (we think) in an enema. I'll update if my husband does actually go ahead and make this.