I started it in January of this year, after using Remicade for the previous three years & creating antibodies to the Remicade. So, like Sweetie, I'm not sure if the Remicade was pushing me into remission prior to starting Humira. But by the time I did start Humira, Remi wasn't do much of anything. After my loading doses, things improved & continued to do so with each bi-weekly injection. I'm not on a plateau, I have morning urgency, 3-6 bm's every morning, then I'm good for the day. I'd say it took a good 2 months of bi-weekly injections to get me where I am today. Keep the faith!