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Posted 3/22/2011 10:48 AM (GMT 0)
Hi all

I noticed in a reply post by MyUC that he gets raised eosinophils when in a flare - which is simmilar to my daughter. I was wondering how many others on the forum get this and if they have investigated allergy connections with any sucess?

Thanks

Sue

 

Posted 3/22/2011 2:17 PM (GMT 0)
It's very common. The body creates and sends them to also fight an infection.
Posted 3/22/2011 6:46 PM (GMT 0)

suenew61:

I investigated this a lot.  As you know my eosinophils went through the roof, about 30k.  Normal 300-600.  So a hundred times more than normal.  I eventually went to two different allergist/immunologist who said there has been reported clinical evidence of this in the past.  They didn't even have to think about it.  They knew right away that this was cause by my colitis.  My GI doc went on to say that a certain subgroup of people have this connection, mostly of Asian descent.  If you want I can post the link to the article.  It was published in the journal of gastroenterology back in the 80's in the UK.  Let me know if would like to read it.  Ask any questions about this and I will be glad to help out.  Unfortunately I know a lot about this.

MyUC

Posted 3/22/2011 11:00 PM (GMT 0)
Hi MyUC I'm glad you spotted my post.
I would love to see the original article even if it is slightly older. On diagnosis my daughter had an eosinophil count of 1.8x10(power)9 cells/L - we are in the UK - with a total white cell count of 11.2x10(power)9 cells/L which calculates that they made up 16% of the total white cell population. This is only 3-4x the top end of normal compared to your 100x normal levels(!!). I work in a hospital lab and have easy access to the analysers and so she has been regularly tested since diagnosis. With steroids she drops rapidly to normal eosinophil levels and following healing/probiotics/SCD diet she then maintains a symptom free remission. Even though she is on 6MP approx. 1-2 months after completing the pred taper I can see her eosinophil levels begin to creep upwards and then spike followed immediatly by a flare even though her total white cell count is never excessively high. She currently has a normal to low IgE blood result, even though she does get asthma and some seasonal allergies. She is having some patch testing done next week to see if we can see any non-IgE mediated allergies, but I was wondering what others have found if they have investigated this direction before.
Thanks
Sue

Post Edited (suenew61) : 3/22/2011 5:04:01 PM (GMT-6)

Posted 3/23/2011 12:57 AM (GMT 0)
MyUC here.  First here is the article,

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2418916/pdf/postmedj00106-0024.pdf

It basically says that eosinophilia is and can be a manifestation of ulcerative colitis.  It's rare but well documented.  I was on prednisone for my colitis on and off for about 10 years.  Eventually prednisone didn't do anything for my elevated wbc/eosinophil count.  The steroids just caused my wbc to continue to elevate.  Hence the Imuran.  That put everything back into check.  I also have occasional asthma and some various allergies.  I went through patch testing but it didn't really come up with anything substantial.  My colonscopies, prior to Imuran, showed abundant eosinophils in my colonic mucosa.  Before the Imuran my colon was heavily affected by my pancolitis.  Once the Imuran healed my colon the eosinophils dropped.  My last colonscopy showed a 98% normal colon.  My bloodwork has showed a normal wbc for the last 2+years and my eosinophil count is now just above normal.  Not even twice normal, it's within a few hundred of normal.  Not only did I see allegist/immunologists but I saw and am seeing an allergist/immunologist that is the clinical director of eosinophilic disorders at one of the best medical teaching institutions in the world. 

Any other question?  I am glad to help.

MyUC


Posted 7/18/2013 3:15 AM (GMT 0)
Hi MyUC

I'm very interested to know if you are still in remission since taking Imuran. Its been over 2 years since your last post. I wonder if you still check this site?

I was recently diagnosed with eosinophilic colitis (last year to be precise). After the first flare I did not have any symptoms again until just recently. I have read that the presence of eosinophils can actually lead to UC, which is maybe what I have now. Not sure because I haven't been for a second scope.

However, I am interested in your success with Imuran. I am also very interested to know who the 'clinical director of eosinophilic disorders at one of the best medical teaching institutions in the world' is. Where is he/she based? Can you give me their name, or a way to get in touch.

Thank you for your post and sharing the article.
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