Fecal Transplant - I took the plunge! PART IV

E coli Nissle had a good success rate in treating UC, however it did not seem to have the ability to permanently colonize, most likely because the other microbes are better adapted to survive in your colon with the other microbes. So, what is really needed is a stable combination of microbes that does include high numbers of the beneficial bacteria like E Coli Nissle. Or maybe one needs to really thoroughly clean the digestive tract with colonics and antibiotics before applying E Coli Nissle rectally many times in an attempt to make it a dominant strain that is able to fight off the other incompatible bacteria.

Some users on this thread and some others here said that that some of them got worse. On the other hand there was a similar study by Dr. McCann who used just 1-5 probiotic strains combined with similar cleansing protocol that resulted in a similar success rate (I purchased the paper below), though he treated fewer patients than Borody. E coli Nissle by itself is proven by relatively large clinical studies, though it requires continuous treatment, but antibiotics improve the remission length (as pointed here: http://www.ardeypharm.de/pdfs/en/mutaflor_drugforlife_e.pdf).

Delarge said...
"In 1994, Dr. Michael L. McCann and colleagues published a paper entitled, "Recolonization Therapy with Nonadhesive Escherichia coli for Treatment of Inflammatory Bowel Disease," in the Journal of the New York Academy of Sciences. This work reported on a process called "reflorastation" and a three-year study that focused on normalizing the bowel bacteria using L. acidophilus (DDS-1 strain), B. bifidum (Malyoth strain), and benign E. coli bacteria (Nissel 1917 strain). Remember, E. coli is a common bowel bacteria that we all carry. With the exception of the lethal H:0157 strain, which contaminates the food chain, most strains of E. coli are harmless. Because they are normal bowel residents they can even be considered beneficial.

Dr. McCann’s study involved patients who suffered from an inflammatory bowel disease, either Crohn’s disease or ulcerative colitis. His reflorastation protocol began with the use of heavy-duty antibiotics and antifungals to completely rid the body of all bacteria—the good as well as the bad. Once the intestines had been thoroughly denuded, the normal bacteria were reintroduced, both orally and via retention enemas. As a result, each patient so treated went into remission, and those who continued with the bacterial supplementation remain disease-free at the time of this writing."

I tried e. coli Nissile and it didn't work. I never tried it from the bottom up though.

I'm almost done with the 10 fecal transplants. Can't tell if they're doing anything, but I have a very sore anus from pushing the internal hemmerhoids aside with the tip every day.

So far that's the only negative...

Stool smells like my daughter's, and we're all very used to the process by now. I meditate or read for an hour, and I've been able to hold them in anywhere from 6 hours to overnnight. (Lately she's been pooping around 11 AM)

I do know two people with UC who got worse with fecal transplants; one reacted badly to his wife's stool, the other got sick with something that was undetected in the fecal sample . (Cant remember what now.) So there is risk, but I still think it's far more likely to help then one single bacteriall strain.

I'm still taking VSL and s. boulardii though, homemade yogurt and saurkraut throughout the day.. Probably for life.

georgie_girl,

Is there a way to contact you? I was on your blog and had a few questions for you.

One had his wife's stool tested and it came back fine. No, I don't think he did the Borody protocol. The other person...I don't remember, sorry. I *think* he had his donor's stool tested. Whether or not he followed the complete protocol, not sure. Sorry I don't have more details.

@subdued.
are you using probiotics during the antibiotics treatment?

7007,

Do you think your fever could have had anything to do with the transplants?

Here's a brand new article on fecal transfusion and the microbiome:

http://www.nature.com/mi/journal/v4/n1/full/mi201079a.html

Well, the fecal tranfusion failed to keep me in remission. Last week's CRP was 16, and symptoms are beginning to regress. darn it!

I was going to try Prochymal, but they just changed the requirements. You can only have failed ONE biologic instead of two.

I'm very discouraged, to say the least. Right now, my only therapy is antibiotics, which I reluctantly started again yesterday.

My doctor wants me to try Cimzia,but I don't have a lot of hope in that; Remicade helped only when I went on
SCD, and after I had surgery to remove some of my descending colon, I was well on SCD alone. Later flared (after antibiotics), and Humira ultimately made me worse.

I have begun LDN again a few nights ago, added boswellia, turmeric, curcumin, and am going to try lactoferrin. I'm getting all 7 of my very large mercury amalgams out in 2 weeks (coincidentally, I was diagnosed when I was 16; the year I got all of them in and braces.) I don't know if that's going to make any difference, but as I cannot wear anything in my ears but gold without redness and itching (and that's a closed wound!), I'm hoping the removal of toxic heavy metals helps me heal better.

I may have to try Cimzia eventually; if it's successful, I will add more worms. (Was in remission for 2.5 years on hookworms alone, but they don't work while you're on antibioitcs, taking 2-8 weeks to "kick in", and my egg count isn't that high, so I really need a larger population, but it's pro-inflammatory at first so I need something to help me get through the initial few months.)

I plan on doing fecal tranfusion again as soon as I find something to help me step off of the antibiotics.

Maybe Crohn's disease doesn't respond the same as UC? I was hoping since my disease is predominantly in my sigmoid and rectum, that it would be useful.

Darn.

Probiotic,

Did you do the prep at all (clean out the colon before doing the procedure)?

7007, can you tell me how you got the worms? I thought they werent fda regulated so we couldnt get them? thanks

Thanks 7007. I will look into them. How are you feeling? I am close in process for the Ft's as you. I am doing my 8th one today. Yesterday was my best one, I got 25 mil in for almost 2 hours. Its hard for me to keep it in for long periods of time and the amount I am supposed to. I feel like I sometimes have more solid stools, but I definitely have more mucus than usual. Its hard to say if Im doing better b/c Im off all of my herbs, lialda and curcumin (18 pills a day), so the question is would I be doing worse off all these if I wasnt doing the FT's? who knows.... Im trying to be patient. I am currently on cimzia, 40 mg oh hydrocortisone (10 mg of prednisone), probiotic, colestrum, and glutathione.
Has anyone on here done infusions and started seeing results weeks after being done with the infusions since it can take a while to "stick"? Thanks!