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Curcumin ameliorates ulcerative colitis, also safe and effective in maintaining remission

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Ulcerative Colitis
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Posted 6/22/2011 7:13 PM (GMT 0)
Curcumin protects against chemically-induced colitis in the mouse model. - Results suggest that curcumin could possibly have a protective role in ulcerative colitis probably via regulation of oxidant/anti-oxidant balance and modulation of the release of some inflammatory endocoids, namely TNF-alpha and NO.Am J Cardiol. 2009 Dec 1 ;104(11):1551-5. PMID: 19932791

Curcumin prevents the development of experimental colitis. In conclusion, the development of DSS-induced colitis was significantly attenuated by curcumin. Being a nontoxic natural dietary product, curcumin could be useful in treatment of IBD patients. Dig Dis Sci. 2007 Nov ;52(11):2993-8. Epub 2007 Apr 11. PMID: 17429738

Curcumin ameliorates experimentally induced ulcerative colitis.- In conclusion, we suggest that inhibition of p38 MAPK signaling by curcumin could explain the reduced COX-2 and iNOS immunosignals and the nitrite production in colonic mucosa reducing the development of chronic experimental colitis. Int Immunopharmacol. 2007 Mar ;7(3):333-42. Epub 2006 Dec 18. PMID: 17276891

Curcumin appears safe and effective in maintaining remission in patients with quiescent ulcerative colitis. - CONCLUSIONS: Curcumin seems to be a promising and safe medication for maintaining remission in patients with quiescent UC. Clin Gastroenterol Hepatol. 2006 Dec;4(12):1502-6. Epub 2006 Nov 13. PMID: 17101300
Posted 6/22/2011 7:26 PM (GMT 0)
I was taking curcurmin capsules at the time of my last flare up. Perhaps I will try them again but it seems like the dose may have been too low or it wasn't the right medicine for maintence for me. I have seen other people here who have a lot more luck with it.
Posted 6/22/2011 8:06 PM (GMT 0)

notsosicklygirl said...
I was taking curcurmin capsules at the time of my last flare up. Perhaps I will try them again but it seems like the dose may have been too low or it wasn't the right medicine for maintence for me. I have seen other people here who have a lot more luck with it.

The capsules didn't work as well for me.  I either mix the powder with a bit of water and drink it, or add the powder to rice as it's cooking (this seems to work the best).

Posted 6/22/2011 8:12 PM (GMT 0)
Can I pour the powwder out of the capsules or would I have to buy new products? I do try to eat turmeric whenever I make a dish where I feel it would compliment the flavors but I understand curcurmin is much more potent?
Posted 6/22/2011 8:47 PM (GMT 0)
Actually I'm using turmeric powder. I buy it by the pound for around $8.00. I use a heaping teaspoon per serving which would take 4-6 cupsules I'm guessing. Seems like that would be a hassle and not very cost effective.
Posted 6/22/2011 8:55 PM (GMT 0)
I have been taking NSI curcumin capsules for nearly a year. Twice recently I passed the contents of a capsule. It was a hard plug with none of the capsule remaining. I took a capsule apart and the contents was a loose powder. Kind of weird. I was thinking maybe heat during shipping fused the powder but no.

I was using a large amount of tumeric before in my homemade granola which is cooked. Wondering if i should go back to that. Indian Dal(hulled lentil bean dish) can be made with large amounts of tumeric and ginger as another use.

about a year ago, the Integrative Medicine program at UofA Tucson(Dr. Weil) was announcing a clinical trial of tumeric on UC. Seems to have disapeared from the news.

I haven't noticed any kind of dramatic effect with curcumin or tumeric but keep taking it along with ginger, milk thistle, yogurt, boswellia, and fish oil because they seem harmless, are cheap and might help somehow. I was able to drop my colazal to 3grams a day and seem to be getting better all the time. I did try to drop colazal down to 1.5 grams/day and that resulted in negative effects within 10 days.
Posted 6/22/2011 8:57 PM (GMT 0)
Bulk tumeric is pretty cheap if you search Amazon. I think I got 3 lbs for $11. It seems to be good quality.

It is supposed to work better if cooked with food containing fat or oil.

I am not clear at all what goes into making curcumin and if it is easily digested(absorbed). Tumeric isn't. It will; actually dye your stools yellow. smilewinkgrin I do know they add ground black pepper to increase absorption in the NSI capsules.

Post Edited (AZYooper) : 6/22/2011 3:01:02 PM (GMT-6)

Posted 6/23/2011 12:43 AM (GMT 0)

AZYooper said...
I do know they add ground black pepper to increase absorption in the NSI capsules.

I think the problems people are having with those capsules is from that black pepper extract "The most common side effects of piperine are gastrointestinal problems such as nausea, vomiting and diarrhea. Consuming excessive amounts of black pepper can irritate the stomach..."

None of the studies include black pepper.

And they aren't studying turmeric, only curcumin: http://www.youtube.com/watch?v=01PcxCgtgr4
Posted 8/5/2011 7:05 AM (GMT 0)
"Patients with UC took 500 mg curcumin twice daily for the first month, and did it thrice daily in the second month. All patients had significant improvements. Forty percent of the patients stopped taking medications; another 40 percent reduced the same, and 20 percent stopped taking them entirely.

Those patients with CD experienced symptomatic improvements (fewer bowel movements, less diarrhea, and less abdominal pain and cramping) after taking 360 mg curcumin thrice daily for the first month, and four times daily for two more months." - http://www.sunstar.com.ph/cebu/lifestyle/2011/08/02/literatus-flame-inflame-170524
Posted 8/5/2011 12:28 PM (GMT 0)
Medz,

Thanks for posting the links to the studies.

Very interesting. I've adding boswellia serrata powder - about 2000mg to my protein shakes as an anti-inflammatory.

I'll have to look into the curcumin.


 

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