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enteric coated lecithin

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Ulcerative Colitis
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Posted 10/8/2011 7:41 AM (GMT 0)
Does anybody know where to get the enteric coated lecithin? It was proven to improve UC in multiple studies. The delayed release PC (rPC) is a patented product by Dr. Wolfgang Stremmel: http://www.freepatentsonline.com/6677319.html and it has been through multiple clinical trials, but it is not currently sold anywhere - I contacted Dr Stremmel and they do not sell it. Another German company Klinipharm sells lecithin granules, but this is not the same as enteric coated lecithin - it is a marine sponge collagen, it has never been through any clinical trials and it might not work at all. So, the only option to get something similar to enteric coated lecithin now could be doing something like this:
https://www.dmt-nexus.me/forum/default.aspx?g=posts&t=14708&p=2
Posted 10/8/2011 11:15 AM (GMT 0)
Dr Stone,

I've read that if you get the wrong kind of lecithin, it can cause stomach cramping and D.

Posted 10/8/2011 12:37 PM (GMT 0)
I've also read that the wrong kind of lecithin can be bad for GI disorders. Infact, the only good lecithin I know of comes from eggs, assuming you're not intolerant of them.
Posted 10/9/2011 1:31 AM (GMT 0)
I don't use lecithin nor have I done any research on it, but in all seriousness, just like other things that you take orally that you want to get "down there", how about popping a little into an enema. People do this for probiotics, vitamin E, etc.
Posted 10/9/2011 2:05 AM (GMT 0)
There was a really long discussion on exactly this in Dec 2010 on this forum. Several people tried the lecithin pills from Klinipharm, though Klinipharm at the time was claiming the pills were made exactly like those used in the studies. It's interesting to see you say the pills are different.

A member on HW (the screen name escapes me) used soy lecithin enemas using granules from Whole Foods to put himself in remission and keep himself there for many years. It was enough to make me try it while trying to slide of prednisone successfully, but it didn't work for me.

I strongly recommend you find the thread discussing everyone's experiences with it if you haven't already.

rPC caps won't be publicly available in the US until they are FDA approved, and that can take years. We likely won't see rPC available by Rx for colitis until the 20teens.
Posted 10/9/2011 10:14 AM (GMT 0)
I don't see the reason why the widely available GRAS lecithin would require FDA approval. If it would, why would not the fish oil require FDA approval as well? Only because the german doctor patented the enteric coated form of it? And yes, Klinipharm sells totally different product - it is not enteric coated lecithin, but rather encapsulated into marine sponge collagen. I am not so sure that the marine sponge could be safe for UC, considering that the marine carrageenan is not. The only thing in common between the rPC and Klinipharm is the first name of the doctor who developed them: Wolfgang, but in Klinipharm it was Wolfgang Schatton and in case of rPC it was Wolfgang Stremmel, they never published papers together and are developing different products.
Posted 10/9/2011 10:25 AM (GMT 0)
I don't see the reason why the widely available GRAS lecithin would require FDA approval. If it would, why would not the fish oil require FDA approval as well? Only because the german doctor patented the enteric coated form of it? And yes, Klinipharm sells totally different product - it is not enteric coated lecithin, but rather encapsulated into marine sponge collagen. I am not so sure that the marine sponge could be safe for UC, considering that the marine carrageenan is not. The only thing in common between the rPC and Klinipharm is the first name of the doctor who developed them: Wolfgang, but in Klinipharm it was Wolfgang Schatton and in case of rPC it was Wolfgang Stremmel, they never published papers together and are developing different products.
Posted 10/9/2011 12:04 PM (GMT 0)
Stremmel product will most likely never be available on the market because the drug will not produce the the financial margin required by pharmas. See the proof right here - went to phase 4 but was discontinued due to lack of financial sponsorship. It is basically just lecithin coated in an entero safe substance (eudragit s100). Any entero coating will do but, according to my compound pharmacist, only a big company has the technology to do it. The trick is to get the lecithin to pass intact through the intestines and reach the colon and then dissolve only in the colon.

http://clinicaltrials.gov/ct2/show/NCT00259571?term=Stremmel&rank=4

http://clinicaltrials.gov/ct2/show/NCT00463619?term=Retarded+Phosphatidylcholine&rank=4

the German pharmacy's product is also covered in eudragit s100, but it's not at the same concentration and not tested. Nobody knows where and how it is released.

It's difficult to do enemas because 1) most commercial lecithin has alcohol and I wouldn't want that on an ulceration and 2) is practically insoluble in either oil or in water and very viscous.

Lecithin strengthens the colon mucosa - a healthy one has a mucus barrier that prevents bacteria to get into the lamina. Ours in damaged and thin and allows the bad stuff to get into our system and create an immune response. Stremmel's studies are free to read on pubmed. In theory, this is/was a great product - zero side effects and remission for steroid depended patients
Posted 10/9/2011 4:44 PM (GMT 0)
There were a handful of people here on HW using the product from Germany with varying degrees of success.
Posted 10/9/2011 10:38 PM (GMT 0)
^^ yes I recall that. I remember some got a bit worse as they couldn't tolerate the coating itself, but if memory serves they couldn't handle Asacol either for the same reason.

Dr Stone, the rPC pills would be patented and sold as a brand name drug available by Rx only, which means FDA approval before being put on the market, regardless of how natural or commonplace the ingredients may be.

Once again, the greed machine prevents something potentially super helpful from getting into the hands of the people who need it most.
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