HealingWell
Search Close Search
☰

CD8+ T-Cell Deficiency, Epstein-Barr Virus Infection, Vitamin D Deficiency, and Steps to Autoimmunit

Support Forums
>
Ulcerative Colitis
✚ New Topic ✚ Reply
1 23
❬ ❬ Previous Thread |Next Thread ❭ ❭
Posted 1/2/2013 6:43 PM (GMT 0)
The virus is very sneaky it is blocking the VDR,vitamin d receptor.

Old Mike

http://link.springer.com/article/10.1007%2Fs00018-010-0441-4#

more on MS

http://www.vitamindwiki.com/Hypothesis%3AVitamin+D+Epstein-Barr+interaction+increases+MS+risk+%E2%80%93+Sept+2011

VDR agonist

http://www.ncbi.nlm.nih.gov/pubmed/19758226

caution extra vitamin D might not be the way to go have to read more on the marshall protocol.

http://www.townsendletter.com/Jan2009/vitaminD0109.htm

http://wanda.uef.fi/uku-vaitokset/vaitokset/2009/isbn978-951-27-1492-5.pdf

more

http://synergyhn.wordpress.com/cga/

Post Edited (Old Mike) : 1/5/2013 10:59:55 AM (GMT-7)

Posted 1/3/2013 1:07 AM (GMT 0)
I have U.C. and have had a positive EB Viral Load for over a year that simply won't come down. I have blood drawn about every 6 weeks and my doctor orders a EBV count with each blood draw. He initially checked this about a year ago prior to me starting imuran (which I never ended up starting, but that is a different story). He checked to make sure my system was ready for the additional immunosuppression. My counts range between 15 K and 67 K. I am convinced and have been convinced for a long time that when my UC symptoms are worse my EB count is high. My GI doctor referred me to an Infectious Disease doctor who put me on Valcyte but this has not cured my EBV. Does anyone else know what there EBV counts is- especially in relation to flare ups? Thanks!
Posted 1/3/2013 1:45 AM (GMT 0)
Well well well,here is a spinach vitamin K connection,at least for ebv cancer genes. Turns them off.

Old Mike

Will see if I can find anything else,been searching for 2 days now and just ran across this.

http://voices.yahoo.com/help-inhibit-epstein-barr-virus-vitamin-k-3644447.html

Cant find anything else on vitamin K

more on vitamin d

 http://www.direct-ms.org/sites/default/files/Holmoy%20Vit%20EBV%20MS%20Med%20Hyp%2007.pdf

Post Edited (Old Mike) : 1/2/2013 7:00:34 PM (GMT-7)

Posted 1/3/2013 3:08 AM (GMT 0)
Mike...

I have an active EBV infection. I can't shake it. Since August I've been feeling the effects (feverish feeling, body aches, fatigue etc...). I had mono in the fall of 2011, which was the first time I was diagnosed with it (at 27 years old). I was diagnosed with UC when I was 18.

I'm currently on Remicade 5mg/Kg, which I believe is allowing this virus to activate. I was feeling better and better until my infusion, then that week I got much much worse again.

I will be setting up an appointment with an infectious disease specialist tomorrow. I meet my GI doc in a few weeks to discuss putting a hold on Remicade.

I did not read any of your links. Can you give me a very quick summary of what you're trying to say with EBV and UC? I would very sincerely appreciate it. I can also have the infectious disease doctor run labs on certain things if you have a reason why it would be pertinent given my situation (UC and EBV).

Thanks!
Posted 1/3/2013 4:24 PM (GMT 0)
OM, do you recall my post which I asked is "vitamin K could it be"?

 I have been doing really well with my spinach and blueberry smoothies which I eat daily in addition to a big bowl of cooked spinach as well as with a big bowl of salad. I think it is great that you found evidence that vitamin K and a link to how it suppresses. It is an amazing correlation. I never been tested for EBV but always had some feeling of being sick and run down. This past few months since fall I only had a cold once. In the past I had been sick 3 times by now. I have to attribute it to my diet change which is heavy spinach in the cooked and raw form. I also only use olive oil when cooking and we actually go through a lot of it. I also use romano cheese to top my cooked bowl of spinach and is funny they mention that also in a link of yours. I think all of these things make sense as they are ways of suppressing the virus. I just never knew that this could be the reason why until you posted a find on it although I always suspected a viral/bug being the cause of all my ailments since my younger years. I plan on getting some of that Ceylon cinnamon soon to add to my diet also.

Thanks again for keeping diligent on this. I will try to keep my head in the mix here but was discouraged a bit and have not been here since my last post. I was taken back a bit on some of the replies I guess but wont let it bother me.

I feel the best I have in a long time but am not completely there...yet.

Steve

Posted 1/3/2013 4:50 PM (GMT 0)
Thoreau: You really need to read the first link I posted.
The basic is that EBV never leaves your body it goes latent in B cells, they should die but become immortal,due to this some form of inflammation starts and autoimmune disease sets up in the target organ. Genetics play a role. This might explain why there is no cure for UC,we can't clear the virus.
But neither can normal people,so of course something else is also going on with us. You may have had ebv as a child and not known it.
Steve: Don't worry yourself,we are all here to beat this if possible.
You just have to remember what works for one person may not work on someone else. In the past have taken lots of vitamin k1,no effect,but will now take it on a regular basis.
Old Mike
Posted 1/3/2013 7:00 PM (GMT 0)
The best I can track down the history of EBV/glandular fever is it is first described in the late 19th century.

Old Mike

http://www.mdconsult.com/books/page.do?eid=4-u1.0-B978-0-443-06839-3..00139-9&isbn=978-0-443-06839-3&type=bookPage&from=content&uniqId=393468585-2

Here is more than you wanted to know about EBV.

http://cs5235.userapi.com/u133638729/docs/cda003112d8c/Tselis_Alex_EpsteinBarr_Virus_386240.pdf

Post Edited (Old Mike) : 1/3/2013 12:06:01 PM (GMT-7)

Posted 1/3/2013 11:12 PM (GMT 0)
OM, I just ate some brussell sprouts around Christmas and noticed that things slowed down for me. They are in the same family as cabbage which has helped me in the past. I was reading today that they are high in Vitamin K. Also sunlight helps me out tremendesly so I am going to read through this post. I like where its going.

On the marshall protocol I digging deep it seems to hurt more than help people so I wouldnt take to much from it.
Posted 1/5/2013 2:53 PM (GMT 0)
A random find,this inhibits the lytic form of EBV. Also used to treat UC. Andrographis

I have tried in the past,no effect but will up the dose.

Old Mike

http://www.ncbi.nlm.nih.gov/pubmed/18981566

http://www.ncbi.nlm.nih.gov/pubmed/21114791

Posted 1/5/2013 5:30 PM (GMT 0)
Going to look more into B cell depletion.

Old Mike

Curcumin high dose.

http://journals.tums.ac.ir/upload_files/pdf/_/21159.pdf

LND is a possible.

http://www.ncbi.nlm.nih.gov/pubmed/20598772

Works but can be a dangerous drug.

http://en.wikipedia.org/wiki/Rituximab

Also causes some form of colitis.

http://www.ncbi.nlm.nih.gov/pubmed/20566611

B cells may actually be good for UC.

http://www.ncbi.nlm.nih.gov/pubmed/17604367

Rituximab does not work on UC.

http://www.ncbi.nlm.nih.gov/pubmed/21471566

THIS WHOLE THEORY MIGHT BE A DEAD END FOR UC.

 

Post Edited (Old Mike) : 1/5/2013 11:02:20 AM (GMT-7)

Posted 1/5/2013 5:52 PM (GMT 0)
Mike where do you get the andrographis from? I've not heard of it before (but have done lots of chinese medicine so perhaps it was in there?) Is it an herb or a mix?
Posted 1/5/2013 5:59 PM (GMT 0)
ANy healthfood store should have it,also I would guess amazon,it is an extract from the herb.
Please read the above post to your last one,B cell depletion may be dangerous and not work.
But EBV may still cause a problem with UC. Just don't know for sure.
Old Mike
Posted 1/7/2013 3:06 PM (GMT 0)
HMPL-004 vs placebo

It appears there is a phase 2 of this in the US right here in Massachusettes. I have a link but it does not tell the outcome of the trial although it says somthing about being completed. I dug deaper and still have not seen any results from some of the links provided to archives. I may call the place that did the trail. In the mean time I will dig more.

http://clinicaltrials.gov/ct2/show/study/NCT00659802

update: chi med talks about a phase 2 of this at their site.

http://www.chi-med.com/eng/business/hmpl004.htm

Mike are you going to take the dose they used in the first trial in china? Let us know how it works for you ok?

Steve

Post Edited (twiggs) : 1/7/2013 8:11:19 AM (GMT-7)

Posted 1/7/2013 4:09 PM (GMT 0)
Well that sucks! I'm going to ignore the b cell stuff as it contradicts all of the other studies and I have no other leads so I'm going with the EBV for now...
Posted 1/7/2013 4:41 PM (GMT 0)
I am on day 2 at 1200mg will ramp to 1800 shortly.
Seems they just did an ethanol water extract,and the stuff we can buy should be about the same as used

in the trial.  Seems to be making hard stool,difficult to get out,perhaps need to eat more veggies at this time.
Old Mike

Post Edited (Old Mike) : 1/7/2013 9:56:13 AM (GMT-7)

Posted 1/7/2013 6:02 PM (GMT 0)
I see a product at Puritans for cheap..what do you think Mike? Is this similiar to what your taking now?

Andrographis Extract 400 mg
400 mg / 90 Vegi Caps
$ 8.99

http://www.puritan.com/herbal-supplements-005/andrographis-400mg-023469

Steve
Posted 1/7/2013 6:10 PM (GMT 0)
They are pretty much the same,I am using 300 mg.
I have not had adverse events yet,but stool is hard. Has not stopped blood.
OM
Posted 1/7/2013 6:30 PM (GMT 0)
OM, I found another chinese compound that has an effect on the EBV. Check it out..

[Inhibition of the expression of Epstein-Barr virus antigens in vitro by Chinese medicine compound "Dongxia wan"].

http://www.ncbi.nlm.nih.gov/pubmed/11503041

Other chinese herbs...

http://www.elotus.org/article/chronic-fatigue-and-chinese-herbal-medicine

Viral infections including influenza, enteroviruses, Epstein-Barr virus (EBV), Human Herpes Virus (HHV) 6 and 7, Parvovirus B19, and Xenotropic Murine Leukemia Retrovirus-related Virus (XMRV) are all identified as potential causative factors for chronic fatigue. Chronic fatigue patients with high levels of EBV and HHV6 responded to valganciclovir in 75% of cases, allowing them to return to normal activity. Chinese herbal medicines with anti-EBV effects include Ju Hua (Flos Chrysanthemi), Ji Xue Teng (Caulis Spatholobi), and Hu Huang Lian (Rhizoma Picrorhizae). Ku Shen (Radix Sophorae Flavescentis) reduces replication of HHV6, and Xiang Ru (Herba Moslae) inhibits cytomegalovirus (CMV) and echovirus.


Steve

Post Edited (twiggs) : 1/7/2013 11:34:52 AM (GMT-7)

Posted 1/7/2013 8:03 PM (GMT 0)
I tend to stay away from chinese herbs now after a bad experience with isatis cooling.
Giving the Andrographis a shot since it has been trialed for UC.
The Rituximab trial was very disappointing.
OM
Posted 1/7/2013 8:13 PM (GMT 0)
Oldmike, I just had to give another shout out to you and say thank you for doing all this research, I wish my BF would do all this and understand when I have a day when I'm mad and not feeling good. He tries really hard but I take a lot out on him. Seriously I think it would be easier to date someone with UC. IDK you just give us hope here I think. Thank you.
Posted 1/7/2013 9:12 PM (GMT 0)
Miracles Thanks: My wife must be a saint,she has had to deal with this since 1980 for me,
I was young strong and healthy at the time,and then,the crap hit the fan.
I am driven,and being simi retired,can spend the time looking at all this info.
Old Mike
Posted 1/8/2013 11:23 PM (GMT 0)
Looks like Andrographis may have some toxicity and not good to take long term.  Many of the toxic effects may not even be known.

http://www.ncbi.nlm.nih.gov/pubmed/10925397

http://www.webmd.com/vitamins-supplements/ingredientmono-973-ANDROGRAPHIS.aspx?activeIngredientId=973&activeIngredientName=ANDROGRAPHIS

http://www.zhion.com/herb/Andrographis/Andrographis_Dosage_Side_Effects.html

Post Edited (Old Mike) : 1/8/2013 5:04:37 PM (GMT-7)

Posted 1/10/2013 2:33 PM (GMT 0)
OM , Does that mean you are discontinuing your protocol with andrographis? If this is not the case you may want to consider drinking more fluids to ease the stresses on your liver and other organs while doing it.

Just a thought,

Steve
Posted 1/10/2013 3:06 PM (GMT 0)
I took up to 1800mg over about 5 days now,did not seem to have an effect,so stopping. I cannot afford to have

any other issues.  If anyone else has remission please let us know.

Old Mike

Posted 1/22/2013 4:22 PM (GMT 0)
FYI, took this herb at 1800 mg for two days and had to stop just like all the other items that boost my immune system, garlic, lactoferrin, arginine, protein shakes, etc it made me worse. I understand the die off but its not that I think its more of immune boosting causing it to attack more or react more.
✚ New Topic ✚ Reply
123