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New UC drug Jan 16th

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Ulcerative Colitis
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Posted 1/9/2013 11:17 PM (GMT 0)
Uceris, it is expected to be released on Jan 16th, it is similar to endocort, but a different delivery method so it dissolves further in the intestines.

Post Edited (Meemers) : 1/17/2013 10:13:21 AM (GMT-7)

Posted 1/9/2013 11:24 PM (GMT 0)
Hmm wonder what it is?? I didn't think Vedolizumab came out until summer or fall this year.
Posted 1/10/2013 12:23 AM (GMT 0)
It's Uceris but I can't find an update on it's approval. I always wondered why a drug like Entocort couldn't be made to deliver further into the colon. It sounds like this might be it. lol
Posted 1/10/2013 12:27 AM (GMT 0)
Anxious to see more about this!

Post Edited (Meemers) : 1/17/2013 10:13:44 AM (GMT-7)

Posted 1/10/2013 12:36 AM (GMT 0)
I would try it instead of Pred. I am not sure the release is 16Jan. That is when the FDA should give final labeling requirements, and it had been said it could take 2 months after that to distribute.

It is the same MMX technology that Lialda uses, so I think it might still be a little light in the left/sigmoid colon.
Posted 1/10/2013 12:38 AM (GMT 0)
How interesting...hope to hear more about it!
B
Posted 1/10/2013 2:21 AM (GMT 0)
Is this US only? Coming to Canada too I hope.
Posted 1/10/2013 6:13 AM (GMT 0)
probably a dumb question but can someone explain the difference between systemic and non systemic steroid? Does this mean this is somehow safer than prednisone? If so that would be a revelation, but I wont get my hopes up.
Posted 1/10/2013 1:54 PM (GMT 0)
I'm not an expert here but I believe systemic means it goes throughout your whole body where nonsystemic means it is more localized. This means the effects would be more in the immediate area and you wouldn't get the all over the body side effects.
Posted 1/10/2013 2:02 PM (GMT 0)
Non systemic means it blocks the inflammation topically, like when you put hydrocortisone cream on an itchy rash. Systemic means it gets into your blood stream and affects the functioning of your immune system in a more broad way by blocking chemical messengers and immune system cells, like white blood cells, and so on. Systemic corticosteroids are big side effect producers and get into almost every part of your body. Budesonide works right at the site of the inflammation, and any that gets absorbed into the blood stream is processed and excreted rapidly by kidneys/liver, so has little systemic effect, and therefore far fewer side effects.
Posted 1/10/2013 2:27 PM (GMT 0)
I will say, I have been on endocort for quite some time now & I have had NONE of the side effects that I read about prednisone. Prednisone terrifies me & my GI knows it so has done all he can to keep me off it.
Posted 1/10/2013 2:29 PM (GMT 0)
I've been watching this drug for about a year and I'm very excited about it's potential. I think it can help those of us that struggle to taper off prednisone. The FDA has approved the labeling for the drug and now we just need the official approval on 1/16. From what I have read, it will take several weeks after approval for the company to make it available but we should have it sometime in the 1st quarter.
Posted 1/10/2013 2:37 PM (GMT 0)
The reg endocort allowed me to drop from 4 lialda a day to 1. Add the coating to this med & I am most certainly will try this! I already know endocort gives me no neg side effects. I gained about 6 lbs. over a 6 month period, but I think that was just my fault, not the drug. Most importantly, no crazy lady!
Posted 1/10/2013 2:44 PM (GMT 0)
I'll definitely ask for this if I need steroids to pull me out of a flare in the future!
Posted 1/10/2013 2:50 PM (GMT 0)
Good info! I'm on pred now. I see my GI in Feb. I will bring this up. May be good way to get off the pred little quicker.
Posted 1/10/2013 4:02 PM (GMT 0)
Found this:

www.empr.com/phase-3-study-update-of-uceris-for-ulcerative-colitis/article/260998/

Looks like it will be for mild to moderate flares. It will be nice to have another low side effect drug that can be used in combination with asacol and rectals.
Posted 1/10/2013 4:32 PM (GMT 0)
I think that most, if not all, of the mesalamine meds are also for mild to moderate flares, I guess because there's a lower chance they alone will pull a person out of a flare if it's a severe one. But that doesn't mean a doc can't prescribe it for a severe flare.

Even if I'm in a severe flare, I'd prefer to give the Uceris a shot before prednisone.
Posted 1/10/2013 8:22 PM (GMT 0)
It's not that it dissolves farther down in the colon...it would start the release probably in the terminal ileum and continue to be released throughout the colon. I think any oral topical will be effective depending on how long it can remain in the specific areas to be released.

That in conjunction with rectals (be it 5ASA or steroid), should help to slow things down enough for it to do its thing.

q
Posted 1/17/2013 5:15 PM (GMT 0)
Looks like this has been approved and will be coming to market very soon!
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