Posted 2/22/2013 3:29 AM (GMT 0)
Someone a while ago asked about other natural sources of TNF Inhibitors as an alternative to Remicade or for non-responders and such. It took me a while to find the paper but here is the cut and paste of it listing not only food types but sources to studies and so on.
I mentioned before eating six fresh red delicious apple peels a day = the same dosing/blood levels of TNF Inhibition as a typical every 8 week remicade infusion. Just well it's not very ummm practical. I'm still looking for the source of this. Will post it when I find it or well.. if I find it.
Then again $3,500+ every 8 weeks isn't all that practical either ;)
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Other inhibitors of tumor necrosis factor action In addition to the TNF antagonists described in this review, pharmacologic agents that either suppress TNF production or block its action have also been examined. For example, the phosphodiesterase inhibitor pentoxifylline inhibits TNF transcription (Doherty et al., 1991), whereas CNI-1493, a tetravalent guanylhydrazone, inhibits TNF translation (Cohen et al., 1996).
Thalidomide has been shown to inhibit TNF action by enhancing TNF mRNA degradation (Moreira et al., 1993). After promising results with thalidomide in a number of chronic diseases, including RA, thalidomide analogues were synthesized (e.g. lenalidomide). These analogues demonstrate both anti-inflammatory and antitumor effects and inhibit TNF production (Galustian et al., 2004).
A number of natural agents derived from fruits and vegetables have also been shown to function as TNF inhibitors. These inhibitors have been the subject of review by Paul et al. (2006). Based on their chemical structure, these natural products can be broadly categorized into polyphenolic and nonphenolic compounds. The polyphenolic compounds include the flavonoids, which are found in relatively high concentration in fruits, vegetables, nuts, and grains. Examples of flavonoids that modulate TNF signaling include naringenin (in grapefruit), resveratrol (in grapes), and quercetin (in garlic and onion). The nonphenolic compounds can be further categorized into alkaloids (e.g., lycorine found in several plant species including the bush lily Clivia miniata), terpenes (e.g., acanthotic acid isolated from Acanthopanax koreanum), fatty acids and their derivatives (e.g., 13-HOA isolated from linoleic acid by corn and rice lipoxygenase), sterols (e.g., guggulsterol isolated from Commiphora mukul gum), and retinoids (e.g., retinoic acid, a vitamin A metabolite). These natural compounds generally function by reducing TNF protein synthesis, reducing TNF release or inhibiting TNF mRNA expression. Additionally, some of these compounds have been found to interfere with various proinflammatory mediators, such as nitric oxide, cyclooxygenase-II, and prostaglandin E2, and are thought to modulate TNF activity or production via these molecules.
Signal transduction pathways and transcription factors have also become targets in the management of chronic inflammatory diseases. Tas et al. (2005) published an extensive review of these pathways and described the progress to date in the development of small molecule inhibitors and gene therapy that target pathways involved in the pathogenesis of RA.
Source: http://www.dxy.cn/upload/TNFantagonist.pdf - Tumor necrosis factor antagonist mechanisms of action: A comprehensive review