A really good page about MTHFR polymorphisms and how they might effect UC

There is a blood panel that has been recommended. Truly, polymorphisms and the treatment of them are bleeding edge. The info is sparse, conflicting and confusing, lol. I'll dig that up.. Traveling and not at my usual computer.

I have high blood ammonia levels.

Disregard what I said about l-methyltetrahydrofolate in light of those other mutations. 677 has more of a methylfolate need.. I was thinking more about it...And I know Comt and l mthf can play badly together. It could also be one of the things you need.. But if you play with supplementing it, start lower, half everything i said above. If you have any anger, depression, mental issues, stop. That's how too much l-mthfr typically manifests from my understanding. You arent going to hurt yourself by testing it out.. But...COMT is an important mutation and I really don't want to give you bad information. You should go over to mthfrsupport, mthfr.net or phoenix rising and talk to those folks. They are really helpful and span the different treatment philosophies and experiments. Also, I didn't say it above because we were just talking about l methyl, but I'm pretty sure one must never sup Lmthf without b12 or you risk methyl trapping.

Post Edited (PathogenKiller) : 6/2/2013 5:11:23 PM (GMT-6)

I wouldnt take the L methyl, especially without b12 until you deal with those other mutations in some way... That reference range is bs, that is a high homocysteine. Im high at 10.6

You need high tryptophan diet, sam-e supplementation , bh4, trimethyline glycol (TMG), lmethyltetrahydrofolate, non methyl or cyan b12 and zinc. Your seratonin is likely quite low. Do you have anxiety? Your dopamine looks like it has the potential to be quite high, sam-e will help that

drbenkim.com/articles-homocysteine.html

Post Edited (PathogenKiller) : 6/12/2013 4:14:35 PM (GMT-6)

Www.23andme.com

Then pay 20.00 to run it through here.
www.mthfrsupport.com/reports-consults/

No folic acid.. Take the hydroxy.


I do believe I've seen a big difference in my whole immune system since starting methylation supports. My colitis was pretty peaceful by the time i started. I think the alleviation of my ammonia burden by sodium butyrate was the last piece of it.

I couldn't make my mind up on what genetic testing to do for awhile and just focused on my known polymorphisms.. I'm waiting for my 23 and me results. I only know I'm heterozygous for 1298 and 677 on MTHFR. I've definitely seen a change in my happiness and patience levels..I can also now see my immune system when looking at my blood.

bookworm, looks good the only thing Id say is if you have any CBS polymorphisms that B6 might not sit well with you, ideally even if you didnt Id like to see it in a P-5-P format. But I do like that they have it balanced with b2, that is smart. How does it make you feel? I take alot more methyl folate and b12 but most folks in the methylation conversation stay with lower dosing.

What are you currently taking, crispy golden? What are your known confections? Did the abx kick off the flare or the nystatin?

I also have Lyme and my last symptoms are fatigue and joint pain, although both are improving since tweaking my protocol.

I say you start with your known polymorphisms and get A 23andme test. You do need to address those two polymorphisms. The studies are mixed an all the other ones, but mthfr is very recognized to contribute to all sorts of havoc.

Thanks for keeping up to date with this PK. I'm still trying to get my head around this all but am sure there's something in this for me. 23andme ship to the UK so may give it a try.

I am interested in this ammonia - I did the Metametrix Organic Acids (urine) test about 4 years ago but never went to see an expert with the results. The one thing that came up out of range at the time was Citrate and it suggested there might be excessive renal ammonia load. Suggestion was to supplement with arginine but I did not because of constant break outs of fever blisters after high arginine foods. Now I'm wondering if this ammonia could be related to the methylation cycle.

London... Interesting. I dont know about a link between citrate and ammonia.. Ill poke around for you.. Did you ever have any kidney stones? Arginine will reactivate any herpes simplex virus like hsv-1 which causes cold sores. Detoxifying ammonia is a huge part of the methylation cycle.

Resurrecting this thread because I did the 23&me test and found that I am homozygous for C677t - not sure if anyone else is still following this stuff?

Now am wondering if the folic acid supplementing, which seemed to make me feel better at first, has something to do with feeling so tired and unwell recently.

Luckily the A1298 is fine.

I don't know if it is significant but BMHT 2, 4 and 8 are all heterozygous. Apparently it has been suggested that phosphatidylcholine can stimulate this pathway - I remember reading about studies about how this was trialled for some with UC - so maybe stimulating this pathway would help me. Also, it is stated that limiting Taurine may be helpful to aid this pathway, I remember reading recently about taurine conjugated bile being a breeding ground for bad bacteria.

Anyway, main upshot is, I suppose, that I should have my homocysteine level tested. My GP will think I am displaying health anxiety if I ask for that I think so more private testing beckons...

Thanks for coming back on this PK.

That was the only homozygous on the methylation report I did at genetic genie. The detox report from that site also showed homozygous on NAT2 R197Q, not yet found what that is involved in.

Haven't run Sterling's app yet, that's the one that is $20? Do you know what else would be checked for on there?

Definitely citrate, not creatinine, creatinine was OK on the organic acids test, on the regular renal function blood tests (done 6 monthly as per NHS protocol as on long term mesalazine) the creatinine usually comes in at low end, just outside the low end range, but doctors have never been interested in that, they say it is a good thing.

Been taking folic acid for a few years now, which apparently is not good. So I will try some methylfolate maybe but mostly going to make sure I eat green veg every day and navy beans a lot. Happily my colon is tolerating that at the moment - when I think of the years passed with so little of that stuff as it was so hard to tolerate for the colon I realise that is probably part of the puzzle of feeling so tired and low.

Also the mthfr probably explains why my B12 was always low (although just within accepted NHS range), have been using sublingual cyanacolbamin, and seen the levels go right up in my blood, but no idea how much the body as been able to take up.

Overall this genetic stuff is fascinating. Thank you so much for bringing this to the board PK because I would have had no idea and may have kept on supplementing folic acid rather than folate in its natural form.