HealingWell
Search Close Search
☰

Vitamin B6 and UC

Support Forums
>
Ulcerative Colitis
✚ New Topic ✚ Reply
❬ ❬ Previous Thread |Next Thread ❭ ❭
Posted 5/25/2012 3:29 PM (GMT 0)
Don's know if there is a real connection or not, just started looking at it.

Old Mike

http://ajpgi.physiology.org/content/301/2/G249.abstract

http://www.ncbi.nlm.nih.gov/pubmed/10763951

http://www.ncbi.nlm.nih.gov/pubmed/21486513?dopt=Abstract

http://www.ncbi.nlm.nih.gov/pubmed/21604334

http://www.ncbi.nlm.nih.gov/pubmed/12526945

new stuff from dec just found 4/1/14

http://www.ncbi.nlm.nih.gov/pubmed/24183308

 

Post Edited (Old Mike) : 4/2/2014 7:55:26 AM (GMT-6)

Posted 6/18/2012 2:21 AM (GMT 0)
Methylation is huge piece of the puzzle and is altered in UC sufferers. The metylation cycle is super complex and is altered by many of the B vitamins including Folic Acid. Insufficient methylation causes elevated homocysteine levels which is often seen in UC sufferers. While I don't think that supplementing or restricting the intake of B vitamins will induce remission, its def something that should be monitored, because it will have other affects on the circulatory system, hair, mood, and allergies (histamine is highly sensitive to the methylation cycle)
Posted 6/15/2013 1:17 PM (GMT 0)
I have been staying away from B6 supplementation due to the above possible associations with  UC,but started it yesterday.  This mouse study would seem to indicate it might be quite necessary, for healing.

The only thing I am doing right this minute is melatonin and B6.

Today minimal blood,but that has happened before,stool quality pretty good.

You have to watch high doses of B6,cn cause other problems.
Old Mike
http://www.ajbasweb.com/ajbas/2011/1051-1060.pdf

inflammation in general

http://www.webmd.com/heart/news/20120619/low-vitamin-b6-linked-to-inflammation

b6 and melatonin production

http://www.ncbi.nlm.nih.gov/pubmed/18250494

seems that mice and men are different

http://www.ncbi.nlm.nih.gov/pubmed/12080281

kids

http://www.ncbi.nlm.nih.gov/pubmed/8872867

and serotonin

http://www.ncbi.nlm.nih.gov/pubmed/3067155

and methylation

http://www.ncbi.nlm.nih.gov/pubmed/22051144

http://www.ncbi.nlm.nih.gov/pubmed/22001823

http://www.ncbi.nlm.nih.gov/pubmed/23661599

Post Edited (Old Mike) : 6/15/2013 8:54:30 AM (GMT-6)

Posted 6/15/2013 3:33 PM (GMT 0)
Use p-5-p(bioavailable b6) and b2 in concert, not just b6 alone. I have a theory that everyone with UC has mthfr, bhmt and CBS polymorphisms. B6 drives the transulfuration pathway. If you have other blocks in methylation, it can also be your worst nightmare. I wouldn't high dose this b.
Posted 6/15/2013 3:36 PM (GMT 0)
Kmoney, woohoo someone else to talk about the importance of methylation!
Posted 6/15/2013 4:07 PM (GMT 0)
I took a B-100 capsule I bought at the health food store a couple of months ago. Within an hour, I had an ocular migraine and head zinging, skin flushing and some other cruddy feelings.

I looked it up It was likeley the B6. I flushed with water and it passed within a couple of hours.

Do you think this could have instigated my flare???
Posted 6/15/2013 4:19 PM (GMT 0)
Here is a nice page on mthfr, may have been posted by pathogen somewhere else,don't know.

Old Mike

http://www.mdjunction.com/forums/lyme-disease-support-forums/medicine-treatments/10127868-mthfr-testing-and-protocols

Posted 6/15/2013 4:49 PM (GMT 0)

geeker said...
I took a B-100 capsule I bought at the health food store a couple of months ago. Within an hour, I had an ocular migraine and head zinging, skin flushing and some other cruddy feelings.

I looked it up It was likeley the B6. I flushed with water and it passed within a couple of hours.

Do you think this could have instigated my flare???


I dont think it instigated your flare.

I dont know that it was the b6, it might have been the niacin. Niacin, especially when you have high histamine can cause all those things. I bet you have high histamine, most UCers do.

You can actually test your histamine load by taking niacin and seeing if you flush.

you need l-methyltetrahydrofolate for c677t

Post Edited (PathogenKiller) : 6/15/2013 11:13:43 AM (GMT-6)

Posted 6/15/2013 4:55 PM (GMT 0)

PathogenKiller said...
Use p-5-p(bioavailable b6) and b2 in concert, not just b6 alone. I have a theory that everyone with UC has mthfr, bhmt and CBS polymorphisms. B6 drives the transulfuration pathway. If you have other blocks in methylation, it can also be your worst nightmare. I wouldn't high dose this b.

Hi Pathogenkiller, I am not a colitis-sufferer but I have crohns everywhere in my GI-tract. My symptoms get worse from all B-vitamins. I see that you have a profound knowledge in geneticts and maybe these symptoms due to Vit-B  have a concrete reason and I could do something about it. My crohn's is extremely severe so that rice butter and fish have been the only food I could tolerate for the last five years. I am also resistant to every drug ( from pentasa to humira, from LDN to hookworm) and now I am trying the amino-acid therapy.

Thank you

 

Posted 6/15/2013 5:12 PM (GMT 0)

chroninator said...
PathogenKiller said...
Use p-5-p(bioavailable b6) and b2 in concert, not just b6 alone. I have a theory that everyone with UC has mthfr, bhmt and CBS polymorphisms. B6 drives the transulfuration pathway. If you have other blocks in methylation, it can also be your worst nightmare. I wouldn't high dose this b.Hi Pathogenkiller, I am not a colitis-sufferer but I have crohns everywhere in my GI-tract. My symptoms get worse from all B-vitamins. I see that you have a profound knowledge in geneticts and maybe these symptoms due to Vit-B have a concrete reason and I could do something about it. My crohn's is extremely severe so that rice butter and fish have been the only food I could tolerate for the last five years. I am also resistant to every drug ( from pentasa to humira, from LDN to hookworm) and now I am trying the amino-acid therapy.
Thank you

Oh, chroninator! Im so sorry you have suffered so long! how is the amino acid therapy working for you? amino acids attempt to bypass these deficits. Have you had any genetics done? I highly recommend getting a panel done for 99.00 through 23andme. Then spend the additional 20.00 to run the results through either livewello or mthfrsupport. I think I like mthfrsupport better but will invest in both.. cause at this point, what's 40 bucks? LOL. I himhawed on who to go through for a bit because I wanted to get my whole family done.. but finally bit the bullet. I know that Im personally heterozygous for 2 important MTHFR polymorphisms and supporting them has made a big difference for me.
Posted 6/15/2013 10:40 PM (GMT 0)
I have too much b6, 148.4 μg/l (8.7 - 27.2 μg/l being the reference range). I was taking a lot for a certain period (40-80mg/day - b6 was included in some supplements I was taking), but that didn't last more than 2 weeks.
Posted 3/19/2016 5:48 PM (GMT 0)
I've waded through all these articles and i'm quite perplexed: is it good or bad to take vitamin B6? What about other B vitamins?
✚ New Topic ✚ Reply