How do you know if medications like 6mp etc are actaully doing more harm then good? I ask this because according to the logic behind the SSI vaccines is that the immune system is at a deficiency rather then being over stimulated which the current believe is.
I hear of people coming off these drugs or some times after a while they don't work. Maybe because its only preventing the inflamation and at the same time reducing white blood counts and macrophages which intime makes colitis even worse?
There has been reported I think that 7/8 people that toke this vaccine are 100% in remission and there are strong remission/response in another 10 people. With the people discontinuing their medication. This vaccine obviously is a successfull treatment.
How do you know, it may seem like these drugs are puting people into remission but how do you know if deep down its actaully making your condition even worse, you wouldn't know because its preventing the symptoms.
Dr. Gunn: Macrophages are important cells of the body’s innate immune system. One of their primary roles is to engulf (through phagocytosis) dying or dead cells, in order to clear/recycle these dead and dying cells. The cells of the tissues in our body have a natural life cycle, measured in days, weeks or months depending on the tissue. When a cell reaches the end of its natural life cycle, it signals to macrophages that it is dying, a process called apoptosis, inviting macrophages to engulf and recycle the cell. When this happens, the macrophage engulfs the cell and sends out anti-inflammatory and ‘tolerance’ signals so that the adaptive immune system (the other major arm of the immune system) doesn’t react against the antigens of the dying cell.
However, if there is a defect or deficiency of macrophage function (i.e., innate
immune system), especially if there is an environmental trigger such as stress
or chronic infection that overwhelms macrophage function, macrophages don’t
clear dying or dead cells efficiently. As a result, not all dying or dead cells
are cleared by macrophages and, when they aren’t cleared, these dead cells
necrose (i.e., break apart) releasing their internal antigens to which the
adaptive immune system reacts, resulting in antibodies against these
self-antigens and autoimmune disease (such as Crohn’s disease). In other words,
while symptoms of autoimmune disease are generally understood to be a result of
an over-reactive adaptive immune system response, we hypothesize that the
underlying trigger/cause may be a defect or deficiency in the innate immune
system (macrophage function).
Based on our preclinical research, we’ve
found that SSI treatment results in recruitment of macrophages to the targeted
organ or tissue (for example, the gastrointestinal tract) with stimulation of
their phagocytosis function, which we believe relieves the defect or deficiency
that may underlie Crohn’s disease. SSIs are made from killed bacterial
components. Injected subcutaneously (i.e., just under the skin), we’ve shown
that SSIs stimulate an innate immune response in the organ or tissue in which
the bacteria commonly causes infection. An SSI made from E. coli stimulates an
innate immune response in the gastrointestinal tract and thus, we are using an
E. coli derived SSI in our Crohn’s disease clinical trials.
Post Edited (Rick123123) : 6/16/2013 6:22:40 AM (GMT-6)