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Posted 7/3/2013 8:59 AM (GMT 0)
http://fhs.mcmaster.ca/main/news/news_2010/ulcerative_colitis_discovery.html

 i  just read the above link ... what are your thoughts about it..????

Posted 7/3/2013 9:42 AM (GMT 0)
Thank you so much for sharing this.
Posted 7/3/2013 10:09 AM (GMT 0)
I think all research is good.

I followed link - article is 3 years old however. This is one of many research topics going on at McMaster University's center for IBD.

Here is hoping they find something soon...
Posted 7/3/2013 10:31 AM (GMT 0)
I read that increased levels of prostaglandin D2 might play a role in hair loss and asthma. I would be willing to go bald for a long term remission of UC.
Posted 7/3/2013 12:08 PM (GMT 0)
i think we all should discuss about it with gi.we have to work equally to eradicate this uc..afterall we are ppl who suffer.
Posted 7/3/2013 12:40 PM (GMT 0)
Has anyone taken niacin for a long period of time? I guess it helps to release prostaglandin D2 in us which is what this article is suggesting helps with UC. If release more prostaglandin D2 we can effectively slow or stave off UC effects?

http://www.ncbi.nlm.nih.gov/pubmed/2475889

I am curious also about how many people that have thinning or balding have either UC or Crohns? It may help understand the link between this prostaglandin D2 or iof there is any correlation. I am reading that people who have hair loss have elevated levels of prostaglandin D2. Does this make any sense?

Foods that are full of niacin are..

http://www.livestrong.com/article/204619-what-foods-are-high-in-niacin/

Post Edited (twiggs) : 7/3/2013 6:49:36 AM (GMT-6)

Posted 7/3/2013 1:20 PM (GMT 0)

twiggs said...
Foods that are full of niacin are..

http://www.livestrong.com/article/204619-what-foods-are-high-in-niacin/

Thanks for this...I was going to ask what foods are high in niacin. Although the "overly large doses of niacin can cause liver damage, rashes or ulcers" does worry me a little.
Posted 7/3/2013 1:40 PM (GMT 0)
yes, thanks for the article, very interesting. I tried taking Niacin a while back and got no positive reaction, maybe some negative, so I quit. Agree with Jax that high Nicacin intake (esp. by supplement) is not a good thing.

McMasters U. seems to be doing good research on UC, I remember them from past reports.. Great to hear.
Posted 7/3/2013 2:48 PM (GMT 0)
It can be problematic to supplement with niacin if you have mthfr/methylation issues so be careful with that and do your research. I'm by far an expert on that stuff but I know that's the case, would have to look up why.
PD2 is a mediator of histamine release I think . I know they check pd2 levels to assess if histamine levels are too high for things like mast cell activation disorder. So, i wonder if it would be a good idea to just supplement with it? Again, not an expert by any means just a thought/question.
As for McMaster - they received a good chunk of money from the province a few years ago for IBD research and i think they've recruited some top researchers, immunologists etc. Good to see things coming from this but hope it means an actual treatment SOON.
Posted 7/3/2013 4:06 PM (GMT 0)
Thanks for posting. I was taking a liquid B complex daily and my cutting it back to weekly (as I was worried about perhaps overdoing the B12 and B6) did coincide with flaring difficulties. No idea though if it was this or another factor that contributed to a flare up. I'd been feeling anxiety rushes in my body and wondered if I was too high on the Bs as my B12 went from bottom of acceptable range to top of acceptable range on testing.

These are the quantities in it
VIEW IMAGE
Posted 7/3/2013 4:28 PM (GMT 0)
killcolitis: I am waiting on the results from 23andme, having done it because so much of what PathogenKiller has posted makes sense to me. Perhaps that was my issue with niacin.

Londonlurker: wise of you to pay attention to what your body is telling you, figure out the "why" later. I notice you take sublingual B. I tried that with good/bad results. Turned out the sublingual has sorbitol and citric acid both of which my gut hates with a passion. I switched to a non-sublingual and now no problems.
Posted 7/3/2013 4:39 PM (GMT 0)
I think it's a great direction to research. Specific prostaglandins can cause havoc (women's periods) or it seems good..who knows. There are many different types...I haven't done much reading on it.

Thanks for posting the link.
q
Posted 7/3/2013 4:42 PM (GMT 0)
A lot of people post on here with the opinion that many people go into remission with UC but that the ones posting here are just the unfortunate few where treatments don't work. This medical article, along with many others, clearly state that "most people are never cured". While I realize there is a difference between remission and cured, many other articles confirm the fact that those of us posting on this website are more the norm than just the unfortunate few. It's more like there is a fortunate few who can achieve remission. Hopefully this research will lead somewhere.
Posted 7/3/2013 5:26 PM (GMT 0)
Ima, we're learning a LOT from that test though I must admit there's good reason for not having this info (psychological, it's terrifying). But I understand so much more about my daughter's symptoms, issues and why she's not responded to various things like paleo long term. Question is what to do about it, it's such a new field and I don't know how much of what's online is made up, incorrect or the right thing. I'm downloading Amy Yasuko's book "Autism Pathways to Recovery" which is big in the austism circles and is all about methylation. It's well above my head but thought I'd pass it on to you incase you're interested (it's free).
Posted 7/3/2013 10:57 PM (GMT 0)

killcolitis said...
Question is what to do about it

For your daughter, I can tell you what I have settled on is my ticket to long remission.
RS diet navy beans, Vitamin A was recently found to control gut inflammation
nightly I make grass fed beef with chili, add to steamed chopped brocoli/caggabe/spinach
wheatgrass is good too, this is working, I stopped RS diet and flared but down from 70mg pred to 20mg in just weeks because this food heals me. I am on a blood thinner yet doing fine. Eating plenty of yogurt and fruit juice with whey protein and ground oats. Seems the power food outweighs the comfort food, downtown I eat one apple fritter and one big cinnamin swirl every day. Vitamin A and Navy beans is so effective.
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