5-ASA that releases at start of small intestines?

Hello. On account of imagardener's article describing IBS as possible low grade inflammation in the small bowel, does anyone know if any of our current available anti-inflammatories (not just mesalazine but sulfalazine too) are designed to become active throughout the small bowel?

I know oral Pentasa releases around the lower end of the small intestines so they prescribe it for CD patients to get thorough coverage of the terminal ileum, but Ive used it without any relief of my IBS symptoms. I'd like to try something that is active throughout ALL of the small intestines to see if i have any IBS relief.

www.ouh.nhs.uk/patient-guide/leaflets/files%5C100722paedmesalazine.pdf

Pentasa releases throughout the entire small intestine apparently.

q

I have had IBS issues for years, and the one drug the helped symptoms of all bowel issues (sometimes hard to tell if it's UC or IBS) was Pentasa. It didn't work great, but worked better than the other 5-asa's.

Max, hypnosis has been shown to really help some IBS patients. There is a program formed that is supposed to help patients. I did all of this. It took 7 one hour sessions with a hypnotist, plus daily practice on my own.

In the end I can't say that it really helped me a ton, but it supposedly helps some people out A LOT.

I honestly don't know why my IBS issues have gotten better. They were still bad on Remicade 10 months out from starting. Then I took Cymbalta for a bit and started dating my fiancee. Somewhere in there that mix of things started helping and I've really done pretty good for a year now.

I take lomotil as needed which slows down my transit time. A couple of those in the morning really helps me throughout the day I think. I still have 1-4 BM's in the morning, but they aren't urgent and then I go through the day peacefully.

Pluot....I just read some of these comments and sent you an email. Wondering if you wouldn't mind checking it out...