Serotonin regulates innate immune responses of colon epithelial cells through NOX2-derived reactive

Mark,and anyone else messing with amino acid therapy, you might find this to be real interesting,came out today.

Old Mike

http://www.ncbi.nlm.nih.gov/pubmed/24524998

Thanks OM - I totally missed this one. I'm going to send it to Lemon to make sure she reads it.

I'd like to dig out an old paper called Seratonin - the Sword and Shield of the Gut (or something like that) and compare the two.

I'm going to take your and Lemon's advise and hold steady -I haven't seen mucus or blood in a long time, and have had essentially perfect poop for about 2 weeks now. So I'm going to keep up with what I'm doing for a while before going back to the AA's.

It's comforting to know maybe I wasn't imaging some of the dramatic increase in mucus and inflammation.

So know we know that
-5HT triggers inflammation
- Estrogen 17 Beta (Estradiol) controls or "glues" the gaps between Epithelial cells to maintain a tight barrier function, and there's a change during menopause or menstruation to estrone and estriol respectively which both are about 80% less potent.

And the two are related I believe.

And for the heck of it let's just thrown in there that sialic acid is produced in large amounts during inflammation, and the ability of bacteria to utilize sialic acid as a carbon source is correlated with their virulence.

Lot's of good info in the last little while.

Having trouble following the technical language here - is serotonin the good or the bad guy here when it comes to inflammation? Can anyone help decipher?

I know we are taught in mental health that SSRI meds will entail stomach upsets for most in the first few weeks.

In this study they directly exposed the rat colons to serotonin,it caused inflammation on its own
and got even worse when they induced colitis,in the exposed to serotonin rats when compared to the none exposed.
But I suspect you need a balance,too much is not good,like eating 20-30 bananas a day,it also can
build up.

Old Mike

Post Edited (Old Mike) : 2/18/2014 4:14:21 PM (GMT-7)

Thanks for sending me this. I am still on the Amino acids. They seem to help me. Canada Mark-the info about estrogens-well, that would explain why women have a hard time during certain times in their cycle. I have always said hormones influence my disease. I haven't had a lot of time to really read this, but it is on my list of things to get done. Thanks again