Posted 3/7/2014 2:44 PM (GMT 0)
I don't have experience in this, there was a thread quite recently where there seemed to be conflicting research on olive oil, with some part of it possibly being counter-productive. I think though IBD not common in high olive oil consuming countries?
Not a scientist but coincidentally just reading a paper about olive leave extract attenuating colitis, not mention of DAO in there so presume the leaf and fruit have different properties?
Tried to post abstract below, sorry for the bad formatting
"Oleuropein Ameliorates Acute Colitis in Mice
Elisa Giner,
†
Isabel Andu
jar,
†
M. Carmen Recio,
†
Jose
Luis R
í
os,
†
Jose
Miguel Cerda
-Nicola
s,
‡
and Rosa M. Giner
*
,
†
†
Departament de Farmacologia, Facultat de Farma
cia, Universitat de Vale
ncia, Av. Vicent Andre
s Estelle
s s/n, 46100 Burjassot
(Valencia) Spain
‡
Departament de Patologia, Facultat de Medicina, Universitat de Vale
ncia, Av. Blasco Iba
n
ez, 15, 46010 Valencia, Spain
ABSTRACT:
Oleuropein, the major secoiridoid in olive tree leaves, possesses a wide range of health promoting properties. It
has recently been shown to exhibit anti-inflammatory activity. We have evaluated the effect of oleuropein on dextran sulfate
sodium (DSS)-induced experimental colitis in mice in order to provide insight into its mechanisms of action. Oral administration
of oleuropein notably attenuated the extent and severity of acute colitis while reducing neutrophil infiltration; production of NO,
IL-1
β
, IL-6, and TNF-
α
; expression of iNOS, COX-2, and MMP-9; and the translocation of the NF-
κ
B p65 subunit to the
nucleus in colon tissue. In LPS-stimulated peritoneal macrophages, the oleuropein metabolite, hydroxytyrosol, was shown to
inhibit NO production, iNOS expression, NF-
κ
B p65 subunit translocation, mRNA expression, and the release of IL-1
β
, IL-6,
and TNF-
α
. These results suggest that the effect of oleuropein on DSS-induced colitis is associated with a decrease in the
production of interleukins and expression of proteins, principally through reduction of NF-
κ
B activation.
KEYWORDS:
oleuropein, dextran sulfate sodium, colitis, rutin, hydroxytyrosol"